ArticlePsychopharmacology2010
Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of varenicline on aspects of inhibitory control in smokers.Psychopharmacology · 2014Trial
- Acetylcholine deficit causes dysfunctional inhibitory control in an aging-dependent manner.Scientific reports · 2022Article
- Translational Research in Nicotine Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats.Journal of psychopharmacology (Oxford, England) · 2020Article
- Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Impact of Substance Use Disorder Pharmacotherapy on Executive Function: A Narrative Review.Frontiers in psychiatry · 2019Review
- The data set describing cognitive performance after varenicline administration in a 3-choice serial reaction time task in rats.Data in brief · 2017Article
- nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives.Schizophrenia research · 2016Review
- Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective.Frontiers in psychiatry · 2016Review
- Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction.Disease models & mechanisms · 2013Review
- Milnacipran enhances the control of impulsive action by activating D₁-like receptors in the infralimbic cortex.Psychopharmacology · 2013Article
- Involvement of cholinergic mechanisms in the behavioral effects of dietary fat consumption.Brain research · 2012Article
- On the Role of Cannabinoid CB1- and μ-Opioid Receptors in Motor Impulsivity.Frontiers in pharmacology · 2012Article
- Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.Psychopharmacology · 2012Article
- Acute nicotine increases both impulsive choice and behavioural disinhibition in rats.Psychopharmacology · 2011Article
- The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleNicotine, a major addictive component of tobacco, has been suggested to provoke impulsivity by activating central alpha4beta2 nicotinic acetylcholine receptors (nAChRs). Although lesion studies have demonstrated the involvement of the medial prefrontal cortex (mPFC) in impulsive action, the precise brain sites responsible for nicotine-induced impulsive action have not been identified.
objectivesOur goal was to determine whether alpha4beta2 nAChRs in the prelimbic cortex (PL) and/or infralimbic cortex (IL), which are subregions of the mPFC, mediate nicotine-induced impulsive-like action in the three-choice serial reaction time task (3-CSRTT).
methodsThe 3-CSRTT is a simple version of five-choice serial reaction time task and a rodent model of impulsive action in which the animal is required to inhibit the response until a light stimulus is presented randomly in one of three holes. Following the completion of the training, rats were bilaterally injected with dihydro-beta-erythroidine (DHbetaE; 6 and 18 microg/side), a selective alpha4beta2 nAChRs antagonist, into the PL or IL before systemic injection of nicotine (0.2 mg/kg, salt, s.c.).
resultsIntra-IL DHbetaE infusions dose-dependently blocked nicotine-induced impulsive-like action, while infusions of DHbetaE into the PL failed to block the effects of nicotine on impulsive-like action.
conclusionThe present results suggest a critical role for alpha4beta2 nAChRs in the IL in mediating the effects of nicotine on impulsive-like action in the 3-CSRTT.
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Registered trials
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