ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2010
Bupropion induced serotonin syndrome: a case report.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 28 citations in OpenAlex.
- Bupropion Mediated Effects on Depression, Attention Deficit Hyperactivity Disorder, and Smoking Cessation.Health psychology research · 2023Article
- Pediatric Bupropion Ingestions in Adolescents vs. Younger Children-a Tale of Two Populations.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020Observational
- Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020Article
- Challenges in a large mixed drug overdose patient.BMJ case reports · 2016Article
- Serotonin Syndrome With Fluoxetine: Two Case Reports.Ochsner journal · 2016Article
- Urinary Incontinence during Sleep Associated with Extended Release Form of Bupropion HCI.Case reports in psychiatry · 2015Article
- Bupropion, bayesian logic and serotonin toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there are no documented cases of serotonin syndrome (SS) following bupropion ingestion alone in the literature, the ability of bupropion to potentiate serotonin levels and lead to SS is known. A 15-year-old boy was found at home hallucinating. He then developed tonic-clonic activity. Upon arrival in the emergency department, he was confused and restless. On exam, he had tachycardia, hypertension, dilated pupils and dry oral mucosa, normal tone and reflexes in his arms, but rigidity and +4 reflexes in his legs with sustained clonus at his ankles. He was admitted and treated with intravenous fluids and lorazepam for his agitation. A urine drug screen (via gas chromatography/mass spectrometry) was positive only for naproxen and bupropion. Serum bupropion and hydroxybupropion levels drawn 17 h after his reported ingestion were 280 (therapeutic range 50-100) and 3,100 ng/mL (therapeutic range <485), respectively. Within 24 h of his admission, the patient was awake with normal vital signs and neurologic exam. To our knowledge, there are only three reported cases demonstrating SS in conjunction with bupropion toxicity; however, none of these were secondary to bupropion alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.