ArticleMolecular biology reports2010
SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Transcriptomic Analysis of Muscle Satellite Cell Regulation on Intramuscular Preadipocyte Differentiation in Tan Sheep.International journal of molecular sciences · 2025Article
- The Role of Lipid Metabolism in Gastric Cancer.Frontiers in oncology · 2022Review
- The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases.Frontiers in cell and developmental biology · 2022Review
- KRAS Affects Adipogenic Differentiation by Regulating Autophagy and MAPK Activation in 3T3-L1 and C2C12 Cells.International journal of molecular sciences · 2021Article
- Elevated expression of FABP3 and FABP4 cooperatively correlates with poor prognosis in non-small cell lung cancer (NSCLC).Oncotarget · 2016Article
- Correlation between Heart-type Fatty Acid-binding Protein Gene Polymorphism and mRNA Expression with Intramuscular Fat in Baicheng-oil Chicken.Asian-Australasian journal of animal sciences · 2015Article
- Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.Science (New York, N.Y.) · 2013Article
- FATP1 silence inhibits the differentiation and induces the apoptosis in chicken preadipocytes.Molecular biology reports · 2013Article
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) impairs the regulation of apoptosis in megakaryocytes by activating NF-κB: a proteomic study.Molecular & cellular proteomics : MCP · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acid-binding protein 5 (Fabp5), exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport. The purpose of this study was to evaluate the role of Fabp5 during adipogenesis. 3T3-L1 preadipocytes were selected as cell differentiation model and short interfering RNAs (siRNA) against Fabp5 (siFabp5) were prepared. Our results showed that two potent siFabp5 specifically inhibited endogenous expression of Fabp5 at both mRNA and protein level. SiFabp5 had little effect on undifferentiated 3T3-L1 fibroblasts. However, during adipocytic induction, 3T3-L1 preadipocytes transfected with siFabp5 significantly reduced cell viability, as well as increased both caspase-3 activity and procaspase-3 cleavage. Furthermore, we illustrated that knockdown Fabp5 inhibited the expression of PPARγ and C/EBPα during adipocytic induction. In conclusion, our data suggests that Fabp5 is crucial in maintaining the viability of preadipocytes during adipogenesis via the activation of Akt cascade, and decreased Fabp5 expression induce differentiating preadipocytes apoptosis via caspase-3 activation.
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