Evidence map›Paper›PMID 20238161›Full record

ReviewHeart failure reviews2010

Resveratrol and red wine, healthy heart and longevity.

Dipak K Das, Subhendu Mukherjee, Diptarka Ray

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Resveratrol and cardiovascular system-the unfulfilled hopes.Irish journal of medical science · 2021
    Review
  5. Review
  6. Article
  7. Review
  8. [Effect of resveratrol on peak bone mass in growing rats].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017
    Article
  9. Review
  10. Article
  11. Resveratrol-poor red wines modulate SIRT1 in human renal cells.Plant foods for human nutrition (Dordrecht, Netherlands) · 2012
    Article
  12. Article
  13. Review
  14. Recent progress in histochemistry and cell biology.Histochemistry and cell biology · 2012
    Review
  15. Article
  16. Article
  17. Review
  18. SIRT3 and cancer: tumor promoter or suppressor?Biochimica et biophysica acta · 2011
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dipak K DasCardiovacular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA. ddas@neuron.uchc.edu
Subhendu Mukherjee
Diptarka Ray
University of Connecticut · US

Funding

PHOSPHOLIPIDS IN MYOCARDIAL REPERFUSION INJURYR01HL034360 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DAS, DIPAK K · 1987 to 2009
$2.8M
MYOCARDIAL PRESERVATION DURING ISCHEMIC ARRESTR01HL022559 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DAS, DIPAK K · 1985 to 2008
$2.7M
SUPEROXIDE RADICALS IN REPERFUSION INJURYR01HL033889 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DAS, DIPAK K · 1986 to 1988
–
NHLBI NIH HHS HL22559NHLBI NIH HHS HL33889NHLBI NIH HHS HL 34360
6 · The paper itself

Abstract

Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

Indexed as

WineAgingAnti-Inflammatory AgentsAntimutagenic AgentsAntioxidantsCardiotonic AgentsChemopreventionFlavonoidsHeartHumansLongevityPhenolsPlatelet Aggregation InhibitorsPolyphenolsResveratrolStilbenesAnti-Inflammatory AgentsAntimutagenic AgentsAntioxidantsCardiotonic AgentsFlavonoidsPhenolsPlatelet Aggregation InhibitorsPolyphenolsResveratrolStilbenes

Identifiers

PMID20238161
OpenAlexW1993446008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.