Evidence map›Paper›PMID 20238087›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2010

Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy.

Christoph Bock, Greg Von Kuster, Konstantin Halachev, James Taylor, Anton Nekrutenko, Thomas Lengauer

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Integrating diverse databases into an unified analysis framework: a Galaxy approach.Database : the journal of biological databases and curation · 2011
    Article
  4. Next generation sequencing based approaches to epigenomics.Briefings in functional genomics · 2010
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christoph BockMax-Planck-Institut für Informatik, Saarbrücken, Germany.
Greg Von Kuster
Konstantin Halachev
James Taylor
Anton Nekrutenko
Thomas Lengauer

Funding

Global Predictions and Tests of Erythroid RegulationR01DK065806 · NIDDK · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI BLOBEL, GERD A, CHIAROMONTE, FRANCESCA · 2004 to 2013
$5.3M
A Genetic Association Research Statistical FrameworkR01HG003646 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LAZARUS, ROSS · 2006 to 2008
$1.5M
An Efficient Lightweight Environment for Biomedical ComputationR01HG004909 · NHGRI · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEKRUTENKO, ANTON · 2009 to 2011
$1.3M
NHGRI NIH HHS 5R01HG003646-02NHGRI NIH HHS R01 HG003646NHGRI NIH HHS R01 HG004909NIDDK NIH HHS R01 DK065806
6 · The paper itself

Abstract

Modern life sciences are becoming increasingly data intensive, posing a significant challenge for most researchers and shifting the bottleneck of scientific discovery from data generation to data analysis. As a result, progress in genome research is increasingly impeded by bioinformatic hurdles. A new generation of powerful and easy-to-use genome analysis tools has been developed to address this issue, enabling biologists to perform complex bioinformatic analyses online - without having to learn a programming language or downloading and manually processing large datasets. In this tutorial paper, we describe the use of EpiGRAPH (http://epigraph.mpi-inf.mpg.de/) and Galaxy (http://galaxyproject.org/) for genome and epigenome analysis, and we illustrate how these two web services work together to identify epigenetic modifications that are characteristics of highly polymorphic (SNP-rich) promoters. This paper is supplemented with video tutorials (http://tinyurl.com/yc5xkqq), which provide a step-by-step guide through each example analysis.

Indexed as

SoftwareComputational BiologyDNA MethylationEpigenesis, GeneticGenomicsInternetPromoter Regions, Genetic

Identifiers

PMID20238087
PMCPMC6529944

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.