ArticleAdvances in experimental medicine and biology2010
RDS in cones does not interact with the beta subunit of the cyclic nucleotide gated channel.
Article in Advances in experimental medicine and biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Molecular basis for photoreceptor outer segment architecture.Progress in retinal and eye research · 2016Review
- The K153Del PRPH2 mutation differentially impacts photoreceptor structure and function.Human molecular genetics · 2016Article
- PRPH2/RDS and ROM-1: Historical context, current views and future considerations.Progress in retinal and eye research · 2016Review
- Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function.Investigative ophthalmology & visual science · 2015Article
- Structural and functional relationships between photoreceptor tetraspanins and other superfamily members.Cellular and molecular life sciences : CMLS · 2012Review
- Differences in RDS trafficking, assembly and function in cones versus rods: insights from studies of C150S-RDS.Human molecular genetics · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Retinal degeneration slow (RDS) is a photoreceptor specific tetraspanin membrane protein. It is expressed in the rim region of rod outer segment (OS) discs and cone OS lamellae. Mutations in RDS cause both rod and cone-dominant retinal degenerations. We have recently shown that RDS functions differently in rods vs. cones, and have used the cone-dominant nrl ( -/- ) and rod-dominant wild-type (WT) murine retinas to study these differences and help understand the mechanism of rod and cone OS biogenesis. We hypothesize that the differential role of RDS in rods vs. cones is in part related to differences in RDS binding partners. RDS has been shown to bind to the GARP portion of the beta subunit of the rod-cyclic nucleotide gated (CNG) channel. This interaction has been hypothesized to play a role in anchoring the disc rim to the rod plasma membrane. In this study we show that RDS does not interact with the cone CNG. Given that cone lamellae are not entirely encased in plasma membrane and therefore may have different anchoring requirements compared with rods, this observation may help explain some of the differential behavior of RDS in rods vs. cones.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.