ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2010
The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Overexpression of Dock180 and Elmo1 in Melanoma is Associated with Cell Survival and Migration.Annals of dermatology · 2023Article
- Gab2 plays a carcinogenic role in ovarian cancer by regulating CrkII.Journal of ovarian research · 2023Article
- Role of ELMO1 in inflammation and cancer-clinical implications.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- microRNA-132 inhibits the proliferation, migration, and invasion of ovarian cancer cells by regulating CT10 oncogenic gene homolog II-related signaling pathways.Translational cancer research · 2020Article
- Article
- MiR-HCC2 Up-regulates BAMBI and ELMO1 Expression to Facilitate the Proliferation and EMT of Hepatocellular Carcinoma Cells.Journal of Cancer · 2019Article
- Dysregulation of miR-126/Crk protein axis predicts poor prognosis in gastric cancer patients.Cancer biomarkers : section A of Disease markers · 2018Article
- Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer.International journal of molecular sciences · 2016Article
- Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation.Cell communication and signaling : CCS · 2015Article
- The clinical implications of Crk-like adaptor protein expression in papillary thyroid microcarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer.Genome biology · 2014Article
- ELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.PloS one · 2014Article
- The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.Genes & cancer · 2013Article
- Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.Nature immunology · 2013Article
- PTPN4 negatively regulates CrkI in human cell lines.Cellular & molecular biology letters · 2013Article
- Pro-survival effect of Dock180 overexpression on rat-derived H9C2 cardiomyocytes.Medical science monitor basic research · 2013Article
- MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Identification of germline genomic copy number variation in familial pancreatic cancer.Human genetics · 2012Article
- PTTG induces EMT through integrin αVβ3-focal adhesion kinase signaling in lung cancer cells.Oncogene · 2012Article
- Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII.Nature chemical biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small GTPases, particularly the Rho family, are key regulators of cell motility and migration. Dock180 was well known for the main target of signal adaptor protein Crk and acted as a guanine-nucleotide exchange factor for small GTPase Rac1. In the present study, Dock180 was found to combine primarily with CrkI other than CrkII, and its association with Elmo1 was also demonstrated in ovarian cancer cell SKOV3. To evaluate the role of Dock180 in human ovarian cancer cell, we performed RNAi-mediated knockdown of Dock180 in SKOV3 cells using small interfering RNA expression vector. In Dock180 knockdown cells, we found that Elmo1 expression and Rac1 activity were decreased simultaneously. By contrast, the expressions of both another Crk-combining molecule C3G and Rap1 activity were observed to increase obviously. Accordingly, all Dock180 knockdown cells present with evident change in cell morphology, reduced cell proliferation, and attenuated cell migration. Taken together, these results suggest that signal transfer of Crk/Dock180/Rac1 is implicated in actin cytoskeleton reorganization and thus in the cell proliferation, motility, invasion, and of human ovarian cancer cell line SKOV3.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.