ArticleJournal of molecular neuroscience : MN2010
Hypoxia inducible factor-1α (HIF-1α) and some HIF-1 target genes are elevated in experimental glaucoma.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Effect of Hypoxia on Adult Müller Glia Cultures.Biomedicines · 2025Article
- Retinal Protection of New Nutraceutical Formulation.Pharmaceutics · 2025Article
- The Identification of New Pharmacological Targets for the Treatment of Glaucoma: A Network Pharmacology Approach.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Antioxidant effect of gallic acid on retinal ganglion cells in glaucoma model.Scientific reports · 2024Article
- Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death.Scientific reports · 2023Article
- Efficacy of bioactive compounds of Chaihu () on glaucomatous optic atrophy through interleukin-6/hypoxia inducible factor-1α signal pathway.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Protective Effects of Pituitary Adenylate-Cyclase-Activating Polypeptide on Retinal Vasculature and Molecular Responses in a Rat Model of Moderate Glaucoma.International journal of molecular sciences · 2023Article
- Natural History of Glaucoma Progression in the DBA/2J Model: Early Contribution of Müller Cell Gliosis.Cells · 2023Article
- Inflammation and retinal degenerative diseases.Neural regeneration research · 2023Review
- Article
- Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma.International journal of molecular sciences · 2022Review
- Ocular Hypertension Results in Hypoxia within Glia and Neurons throughout the Visual Projection.Antioxidants (Basel, Switzerland) · 2022Article
- Vascular endothelial growth factor-165b protects the blood-retinal barrier from damage after acute high intraocular pressure in rats.International journal of ophthalmology · 2022Article
- Optical Coherence Tomography and Glaucoma.Annual review of vision science · 2021Review
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Altered Iris Aquaporin Expression and Aqueous Humor Osmolality in Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Anti-inflammatory Effects of GTE in Eye Diseases.Frontiers in nutrition · 2021Review
- Protective effect of the extremolytes ectoine and hydroxyectoine in a porcine organ culture.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis.Translational vision science & technology · 2020Article
- Angiogenic and inflammatory biomarker levels in aqueous humor and vitreous of neovascular glaucoma and proliferative diabetic retinopathy.International ophthalmology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Low levels of hypoxia have been suggested to be a mechanism of retinal damage in glaucoma. To test the hypothesis that the activation of the hypoxia-responsive transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) is involved in the pathophysiology of glaucoma, we used a rat model of glaucoma to study (1) HIF-1alpha retinal protein levels by immunoblot analysis, (2) cellular localization of HIF-1alpha in the retina by immunohistochemistry, and (3) expression of retinal HIF-1 gene targets by quantitative real-time polymerase chain reaction. Glaucoma was unilaterally induced in rats by injecting hypertonic saline in episcleral veins. We find that HIF-1alpha protein was increased in the retina following elevation of intraocular pressure, specifically in Müller glia and astrocytes but not in activated microglia. Eight established HIF-1 target genes were measured in experimental glaucoma. Retinal Epo, Flt-1, Hsp-27, Pai-1, and Vegfa mRNA levels were increased and Et-1, Igf2, and Tgfbeta3 levels were decreased in the glaucomatous retinas. Thus, the increase in HIF-1alpha levels in Müller glia and astrocytes is accompanied by a marked up regulation of some, but not all, HIF-1 transcriptional targets. These data support the hypothesis that HIF-1alpha becomes transcriptionally active in astrocytes and Müller cells but not microglia or neurons in glaucoma, arguing against a global hypoxia stimulus to the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.