Evidence map›Paper›PMID 20237805›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life.

S B Jensen, A M L Pedersen, A Vissink, E Andersen, C G Brown, A N Davies, J Dutilh, J S Fulton, L Jankovic, N N F Lopes and 14 more

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06465628 (Effect of Self-administered Acupressure for Improving Xerostomia in Head and Neck Cancer Patients), which is not on this map. Cited by 192 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 12 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06465628 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Self-administered Acupressure for Improving Xerostomia in Head and Neck Cancer Patients: a Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2024 to 2027Enrolled126ConditionsHead and Neck Cancer, XerostomiaArmsSelf-administered acupressure, Oral health education
3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 12 syntheses or guidelines pooled it, 466 citations in OpenAlex.

  1. Pooled it
  2. A systematic review of salivary gland hypofunction and/or xerostomia induced by non-surgical cancer therapies: prevention strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  3. MASCC/ISOO Clinical Practice Statement: Clinical assessment of salivary gland hypofunction and xerostomia in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Guideline
  4. The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  12. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010
    Pooled it
  13. A randomized controlled trial comparing the effect of salivary substitute and fluoride varnish on radiation caries in irradiated head and neck cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
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132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 17 institutions in 9 countries.

S B JensenDepartment of Oral Medicine, University of Copenhagen, Copenhagen, Denmark. sbe@odont.ku.dk
A M L Pedersen
A Vissink
E Andersen
C G Brown
A N Davies
J Dutilh
J S Fulton
L Jankovic
N N F Lopes
A L S Mello
L V Muniz
C A Murdoch-Kinch
R G Nair
J J Napeñas
A Nogueira-Rodrigues
D Saunders
B Stirling
I von Bültzingslöwen
D S Weikel
L S Elting
F K L Spijkervet
M T Brennan
Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
Carolinas Medical Center · USCentro de Pesquisas Oncológicas · BRUniversity Medical Center Groningen · NLUniversity of Copenhagen · DKGriffith University · AUHerlev Hospital · DKIndiana University – Purdue University Indianapolis · USRoyal Marsden Hospital · GBSudbury Regional Hospital · CASupport group for adolescents and children with cancer · BRThe University of Texas MD Anderson Cancer Center · USUniversidade Federal de São Paulo · BRUniversity of Belgrade · RSUniversity of Delaware · USUniversity of Gothenburg · SEUniversity of Maryland, Baltimore · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies.

methodsThe electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article.

resultsThe inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy.

conclusionsSalivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.

Indexed as

Evidence-Based Emergency MedicineHumansNeoplasmsPractice Guidelines as TopicPrevalenceQuality of LifeSalivary Gland DiseasesSeverity of Illness IndexXerostomia

Identifiers

PMID20237805
OpenAlexW2154612768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.