ArticleHistochemistry and cell biology2010
Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts.
Article in Histochemistry and cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Spatial transcriptomics reveals compartment-specific cytotoxic T cell crosstalk with AT2 and goblet cells in advanced COPD.Biomarker research · 2026Article
- Serum vesicle biomarkers reflect the disease activity of idiopathic pulmonary fibrosis.Journal of translational medicine · 2025Article
- Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy.bioRxiv : the preprint server for biology · 2024Article
- Subversion of a family of antimicrobial proteins byFrontiers in cellular and infection microbiology · 2024Article
- BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- BPIFA1 is a secreted biomarker of differentiating human airway epithelium.Frontiers in cellular and infection microbiology · 2022Article
- Identification of Mucus-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease: A Latent Profile Analysis Based on MUC5B-Associated Genes.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Molecular biology of BPIFB1 and its advances in disease.Annals of translational medicine · 2020Review
- Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Identification ofGenetics · 2017Article
- Assessment ofVeterinary medicine international · 2017Article
- Identification and quantification of novel RNA isoforms in horn cancer of Bos indicus by comprehensive RNA-Seq.3 Biotech · 2016Article
- HYOU1, Regulated by LPLUNC1, Is Up-Regulated in Nasopharyngeal Carcinoma and Associated with Poor Prognosis.Journal of Cancer · 2016Article
- A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus.Scientific reports · 2015Article
- LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation.Oncogene · 2014Article
- Macrophages are required for dendritic cell uptake of respiratory syncytial virus from an infected epithelium.PloS one · 2014Article
- PLUNC proteins positivity in patients with chronic rhinosinusitis: a case-control study.TheScientificWorldJournal · 2014Article
- Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.Cell and tissue research · 2012Article
- BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease.Histochemistry and cell biology · 2012Article
- RNA-Seq quantification of the human small airway epithelium transcriptome.BMC genomics · 2012Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Long PLUNC1 (LPLUNC1, C20orf114) is a member of a family of poorly described proteins (PLUNCS) expressed in the upper respiratory tract and oral cavity, which may function in host defence. Although it is one of the most highly expressed genes in the upper airways and has been identified in sputum and nasal secretions by proteomic studies, localisation of LPLUNC1 protein has not yet been described. We developed affinity purified antibodies and localised the protein in tissues of the human respiratory tract, oro- and nasopharynx. We have complemented these studies with analysis of LPLUNC1 expression in primary human lung cell cultures and used Western blotting to study the protein in cell culture secretions and in BAL. LPLUNC1 is a product of a population of goblet cells in the airway epithelium and nasal passages and is also present in airway submucosal glands and minor glands of the oral and nasal cavities. The protein is not expressed in peripheral lung epithelial cells. LPLUNC1 is present in bronchoalveolar lavage fluid as two glycosylated isoforms and primary airway epithelial cells produce identical proteins as they undergo mucociliary differentiation. Our results suggest that LPLUNC1 is an abundant, secreted product of goblet cells and minor mucosal glands of the respiratory tract and oral cavity and suggest that the protein functions in the complex milieu that protects the mucosal surfaces in these locations.
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Registered trials
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