ArticleJournal of exposure science & environmental epidemiology2010
Determinants of serum cotinine and hair cotinine as biomarkers of childhood secondhand smoke exposure.
Article in Journal of exposure science & environmental epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Simultaneous Analysis of Biomarkers in Human Hair for Evaluating Chronic Tobacco Smoke Exposure and Stress/Relaxation Using Online In-Tube Solid-Phase Microextraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry.Molecules (Basel, Switzerland) · 2026Article
- Article
- Behavioral and Pharmacokinetic Assessment of Nicotine e-Cigarette Inhalation in Female Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Sex disparities in the association between serum cotinine and chronic kidney disease.Tobacco induced diseases · 2024Article
- Cotinine as a Sentinel of Canine Exposure to Tobacco Smoke.Animals : an open access journal from MDPI · 2023Article
- CYP2D in the brain impacts oral hydrocodone analgesia in vivo.Neuropharmacology · 2022Article
- Association between objective measures and parent-reported measures of child tobacco smoke exposure: A secondary data analysis of four trials.Tobacco induced diseases · 2022Article
- Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke.Clinical and translational science · 2021Article
- Association between Second-hand Smoke Exposure and Urinary NNAL Level in Korean Adolescents.Journal of Korean medical science · 2021Article
- Comparison of Liquid Chromatography Mass Spectrometry and Enzyme-Linked Immunosorbent Assay Methods to Measure Salivary Cotinine Levels in Ill Children.International journal of environmental research and public health · 2020Article
- Associations between Exposure to Tobacco Smoke and Behavioral Problems in Preschool Japanese Children.Journal of environmental and public health · 2020Article
- The Secondhand Smoke Exposure Scale (SHSES): A hair nicotine validated tool for assessing exposure to secondhand smoke among elderly adults in primary care.Tobacco prevention & cessation · 2017Article
- Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers.Drug and alcohol dependence · 2016Article
- Serum cotinine and whole blood folate concentrations in pregnancy.Annals of epidemiology · 2014Article
- Association of maternal smoking with child cotinine levels.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Article
- Secondhand smoke exposure at home in rural China.Cancer causes & control : CCC · 2012Article
- Evidence for respiratory viruses interactions in asymptomatic preschool-aged children.Allergologia et immunopathologiaArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Understanding the determinants of childhood secondhand smoke (SHS) exposure is important in measuring and preventing exposure to this widespread environmental contaminant. We evaluated the ability of a broad set of factors to explain variability in serum cotinine, reflecting recent exposure, and hair cotinine, reflecting longer-term exposure. We included repeated measures from 223 elementary-school-age asthmatic children residing with a smoker. We used a manual model-building approach and likelihood ratio tests to select a model predicting each biomarker, and also compared the predictive ability of determinants using Akaike Information Criteria. Potential determinants included a comprehensive parent questionnaire, household nicotine, home ventilation characteristics, exposure in vehicles and others' homes, child demographics, and family social class. Variables in each of these categories remained in the final model for both serum (R(2) of 0.61) and hair cotinine (R(2) of 0.45). A comprehensive set of factors was required to best predict cotinine. Studies should use biomarkers for the best quantitative assessment of SHS exposure. Hair cotinine may be a problematic measure because it was highly influenced by racial differences that were unexplained by SHS exposure. When biospecimen collection is not possible, a household nicotine measurement is warranted. If only questionnaires are available, multiple questions are required to best characterize exposure, such as number of cigarettes, hours spent in a room with concurrent smoking, maternal smoking, and approximate home size.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.