ArticleJournal of perinatology : official journal of the California Perinatal Association2010
The changing pattern of inhaled nitric oxide use in the neonatal intensive care unit.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Increase in the use of inhaled nitric oxide in neonatal intensive care units in England: a retrospective population study.BMJ paediatrics open · 2021Trial
- Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response.BMC pediatrics · 2019Trial
- Hospital variation in nitric oxide use for premature infants.Pediatrics · 2012Trial
- Sildenafil as Bridge Therapy for Inhaled Nitric Oxide in Preterm Neonates.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Article
- Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study.Frontiers in pharmacology · 2024Article
- Current diagnosis and treatment practice for pulmonary hypertension in bronchopulmonary dysplasia-A survey study in Germany (PUsH BPD).Pulmonary circulation · 2023Article
- Respiratory management and bronchopulmonary dysplasia in extremely preterm infants: a comparison of practice between centres in Oxford and Melbourne.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Inhaled nitric oxide use in neonates: Balancing what is evidence-based and what is physiologically sound.Nitric oxide : biology and chemistry · 2020Review
- Early inhaled nitric oxide in preterm infants <34 weeks with evolving bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Inhaled nitric oxide use in preterm infants in California neonatal intensive care units.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Management of hypoxemic respiratory failure and pulmonary hypertension in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2016Review
- Inhaled nitric oxide usage in preterm infants in the NICHD Neonatal Research Network: inter-site variation and propensity evaluation.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Increased risk for respiratory distress among white, male, late preterm and term infants.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
- Guidelines for Rational and Cost-Effective Use of iNO Therapy in Term and Preterm Infants.Journal of clinical neonatology · 2012Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to evaluate the demographic characteristics and outcomes of neonates who were admitted to a neonatal intensive care unit and treated with inhaled nitric oxide (iNO) during the years 2000-08. The goal of studying this group of neonates was to evaluate how iNO use has evolved in infants and to estimate the frequency of off-label use of this drug in this population. STUDY
designRetrospective review of the Pediatrix Clinical Data Warehouse de-identified data set. Pediatrix Medical Group provides intensive care services in 244 hospitals in 32 states and Puerto Rico. Nine (3.7%) centers provide extracorporeal membrane oxygenation.
resultThere were 494 255 neonates in the data set; 4316 (0.9%) were treated with iNO. The use of iNO increased from 154 of 32 967 patients in 2000 to 921 of 75 911 patients in 2008; a 2.6-fold increase (0.47 to 1.23%). There were 155 872 infants <34 weeks estimated gestational age discharged between 1 January 2000 and 31 December 2008; 1656 (1.1%) were treated with iNO. Since approval in 2000, the reported use of iNO in neonates <34 weeks increased from 0.3 to 1.8% in 2008; a sixfold increase in the reported use of iNO. The biggest increase occurred in infants between 23 and 26 weeks' gestational age (0.8 to 6.6%). In contrast, the increase in iNO use among neonates born ≥34 weeks has only increased from 0.5 to 1%.
conclusionThe use of iNO has increased and the greatest increase has been the off-label use among preterm neonates.
Indexed as
Identifiers
20237489What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.