ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Dendritically localized transcripts are sorted into distinct ribonucleoprotein particles that display fast directional motility along dendrites of hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 81 citations in OpenAlex.
- Multiplexed smFISH Reveals the Spatial Organization of Neuropil Localized mRNAs Is Linked to Abundance.eNeuro · 2025Article
- How energy determines spatial localisation and copy number of molecules in neurons.Nature communications · 2025Article
- RNA granules in flux: dynamics to balance physiology and pathology.Nature reviews. Neuroscience · 2024Review
- The kinesin-3 KIF1C undergoes liquid-liquid phase separation for accumulation of specific transcripts at the cell periphery.The EMBO journal · 2024Article
- Statistical modeling of mRNP transport in dendrites: A comparative analysis of β-actin and Arc mRNP dynamics.Traffic (Copenhagen, Denmark) · 2023Article
- RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration.International journal of molecular sciences · 2022Review
- Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus.Life science alliance · 2022Article
- Illuminating RNA biology through imaging.Nature cell biology · 2022Review
- Article
- Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation.Cell reports · 2021Article
- A kinesin adapter directly mediates dendritic mRNA localization during neural development in mice.The Journal of biological chemistry · 2020Article
- Polysomes identified by live imaging of nascent peptides are stalled in hippocampal and cortical neurites.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Live cell imaging reveals 3'-UTR dependent mRNA sorting to synapses.Nature communications · 2019Article
- Nanoscale imaging reveals miRNA-mediated control of functional states of dendritic spines.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells.Nucleic acids research · 2019Article
- Shifting patterns of polyribosome accumulation at synapses over the course of hippocampal long-term potentiation.Hippocampus · 2018Article
- Imaging Single-mRNA Localization and Translation in Live Neurons.Molecules and cells · 2016Review
- Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.Molecular & cellular proteomics : MCP · 2016Article
- The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity.Non-coding RNA · 2016Review
- Single-molecule insights into mRNA dynamics in neurons.Trends in cell biology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Localization of mRNAs to postsynaptic sites and their subsequent translation is thought to contribute to synapse-specific plasticity. However, the direct visualization of dendritic RNA transport in living neurons remains a major challenge. Here, we analyze the transport of Alexa-labeled RNAs microinjected into mature hippocampal neurons. We show that microinjected MAP2 and CaMKIIalpha RNAs form particles that localize into dendrites as their endogenous counterparts. In contrast, nonlocalizing RNAs or truncated CaMKIIalpha, lacking the dendritic targeting element, remain in the cell body. Furthermore, our microinjection approach allowed us to identify a novel dendritically localized RNA, Septin7. Time-lapse videomicroscopy of neurons injected with CaMKIIalpha and Septin7 RNAs demonstrates fast directional movement along the dendrites of hippocampal neurons, with similar kinetics to Staufen1 ribonucleoprotein particles (RNPs). Coinjection and simultaneous visualization of two RNAs, as well as double detection of the corresponding endogenous RNAs, reveal that neuronal transcripts are differentially sorted in dendritic RNPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.