ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 85 citations in OpenAlex.
- Peripheral Myelin Protein-22 and Its Prominence in Charcot-Marie-Tooth Disease.Chemical reviews · 2026Review
- Characterising PMP22-Proximal Partners in a Schwann Cell Model of Charcot-Marie-Tooth Disease Type1A.Biology · 2025Article
- Long-Term Changes of Physiological Reactions in Young Lipizzan Stallions During Exercise Testing.Animals : an open access journal from MDPI · 2025Article
- Altered epithelial development of the lateral ventricle choroid plexus in Mllt11 mutants.Biology open · 2025Article
- Schwann Cell Development and Myelination.Cold Spring Harbor perspectives in biology · 2024Review
- Review
- Cellular mechanisms of heterogeneity in NF2-mutant schwannoma.Nature communications · 2023Article
- Traumatic and Diabetic Schwann Cell Demyelination Is Triggered by a Transient Mitochondrial Calcium Release through Voltage Dependent Anion Channel 1.Biomedicines · 2022Article
- SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages.Cell & bioscience · 2021Article
- Myelin Biology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- De novo variants in MPP5 cause global developmental delay and behavioral changes.Human molecular genetics · 2020Article
- aPKC in neuronal differentiation, maturation and function.Neuronal signaling · 2019Review
- Article
- The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system.Histochemistry and cell biology · 2019Article
- Modulation of Neural Activity for Myelination in the Central Nervous System.Frontiers in neuroscience · 2019Review
- Differential effects of myostatin deficiency on motor and sensory axons.Muscle & nerve · 2017Article
- Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system.Histochemistry and cell biology · 2017Article
- Wallerian demyelination: chronicle of a cellular cataclysm.Cellular and molecular life sciences : CMLS · 2017Review
- The Par3 polarity protein is an exocyst receptor essential for mammary cell survival.Nature communications · 2017Article
- Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells.Molecular neurobiology · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diameter, organization, and length of the myelin sheath are important determinants of the nerve conduction velocity, but the basic molecular mechanisms that control these parameters are only partially understood. Cell polarization is an essential feature of differentiated cells, and relies on a set of evolutionarily conserved cell polarity proteins. We investigated the molecular nature of myelin sheath polarization in connection with the functional role of the cell polarity protein pals1 (Protein Associated with Lin Seven 1) during peripheral nerve myelin sheath extension. We found that, in regard to epithelial polarity, the Schwann cell outer abaxonal domain represents a basolateral-like domain, while the inner adaxonal domain and Schmidt-Lanterman incisures form an apical-like domain. Silencing of pals1 in myelinating Schwann cells in vivo resulted in a severe reduction of myelin sheath thickness and length. Except for some infoldings, the structure of compact myelin was not fundamentally affected, but cells produced less myelin turns. In addition, pals1 is required for the normal polarized localization of the vesicular markers sec8 and syntaxin4, and for the distribution of E-cadherin and myelin proteins PMP22 and MAG at the plasma membrane. Our data show that the polarity protein pals1 plays an essential role in the radial and longitudinal extension of the myelin sheath, likely involving a functional role in membrane protein trafficking. We conclude that regulation of epithelial-like polarization is a critical determinant of myelin sheath structure and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.