ArticleThe Journal of clinical endocrinology and metabolism2010
Human labor is associated with reduced decidual cell expression of progesterone, but not glucocorticoid, receptors.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Molecular Changes on Maternal-Fetal Interface in Placental Abruption-A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Interleukin-1 Receptor Accessory Protein Amplifies Trophoblast Inflammatory Signaling in Inflammation-Associated Preterm Birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts.The American journal of pathology · 2024Article
- Expression of the Costimulatory Molecule B7-H4 in the Decidua and Placental Tissues in Patients with Placental Abruption.Biomedicines · 2022Article
- Decidual cell FKBP51-progesterone receptor binding mediates maternal stress-induced preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Thrombin-Induced Decidual Colony-Stimulating Factor-2 Promotes Abruption-Related Preterm Birth by Weakening Fetal Membranes.The American journal of pathology · 2020Article
- Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Cervix Stromal Cells and the Progesterone Receptor A Isoform Mediate Effects of Progesterone for Prepartum Remodeling.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Birth and Neonatal Transition in the Guinea Pig: Experimental Approaches to Prevent Preterm Birth and Protect the Premature Fetus.Frontiers in physiology · 2018Review
- Agonist-Dependent Downregulation of Progesterone Receptors in Human Cervical Stromal Fibroblasts.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions.The Journal of clinical investigation · 2013Article
- Abruption-induced preterm delivery is associated with thrombin-mediated functional progesterone withdrawal in decidual cells.The American journal of pathology · 2012Article
- Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Article
- Comparison of Risk of Preterm Labor between Vaginal Progesterone and17-Alpha-Hydroxy-Progesterone Caproate in Women with Threatened Abortion: A Randomized Clinical Trial.International journal of fertility & sterilityArticle
- Role of nuclear progesterone receptor isoforms in uterine pathophysiology.Human reproduction updateReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
contextUnchanging plasma progesterone (P4) levels suggest that human labor is initiated by reduced P4 receptor (PR) expression, which elicits functional P4 withdrawal. The glucocorticoid receptor (GR) is also implicated in this process.
objectiveOur objective was to compare PR and GR staining in human decidual cells (DCs) and interstitial trophoblasts (ITs) of gestational age-matched pre- and postcontraction specimens and to evaluate steroid effects on PR and GR expression in human DC cultures. INTERVENTIONS AND
main outcome measuresDecidua basalis and parietalis sections were immunostained for PR or GR and then for the cytoplasmic DC and IT markers vimentin and cytokeratin. Western blotting measured PR and GR levels in nuclear extracts of cultured leukocyte-free term DCs after incubation with estradiol-17beta (E2) with or without medroxyprogesterone acetate (MPA).
resultsPR histological scores (HSCOREs) were significantly higher in DC nuclei from pre- vs. post-uterine-contraction decidua basalis and parietalis sections with PR immunostaining absent from ITs. In contrast, immunoreactive GR was localized in IT and DC nuclei. GR HSCORES were significantly higher in ITs than DCs but similar in pre- vs. post-uterine-contraction specimens. In term DC monolayers, PR-A and PR-B were enhanced by E2 and inhibited by MPA, whereas E2 plus MPA produced intermediate PR expression. The GR was constitutively expressed.
conclusionsIn post- vs. pre-uterine-contraction specimens, significantly lower HSCOREs in DC nuclei, but not IT, and unchanging GR levels in DCs and ITs suggest that functional P4 withdrawal may occur in DCs and is unlikely to involve the GR. Nuclear extracts from DC monolayer cultures express steroid-regulated PR-A and PR-B and constitutive GR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.