ArticleMolecular biology of the cell2010
Yip1A structures the mammalian endoplasmic reticulum.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Article
- YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation.Journal of virology · 2025Article
- Yip1 interacting factor homolog B mediates the unconventional secretion of ORF8 during SARS-CoV-2 infection.iScience · 2025Article
- Plasticity and structural alterations of mitochondria and sarcoplasmic organelles in muscles of mice deficient in α-dystrobrevin, a component of the dystrophin-glycoprotein complex.Human molecular genetics · 2024Article
- Pancreatic beta cell ER export in health and diabetes.Frontiers in endocrinology · 2023Review
- Exploring the eukaryotic Yip and REEP/Yop superfamily of membrane-shaping adapter proteins (MSAPs): A cacophony or harmony of structure and function?Frontiers in molecular biosciences · 2022Review
- Review
- YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.The Journal of clinical investigation · 2020Article
- Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells.Viruses · 2020Article
- BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication.Journal of virology · 2020Article
- When STING Meets Viruses: Sensing, Trafficking and Response.Frontiers in immunology · 2020Review
- Characteristics and Functions of the Yip1 Domain Family (YIPF), Multi-Span Transmembrane Proteins Mainly Localized to the Golgi Apparatus.Frontiers in cell and developmental biology · 2019Review
- ER Dynamics and Derangement in Neurological Diseases.Frontiers in neuroscience · 2018Review
- Functional characterisation of the YIPF protein family in mammalian cells.Histochemistry and cell biology · 2017Article
- Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response.Cell death & disease · 2017Article
- Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection.PLoS pathogens · 2015Article
- Yip1B isoform is localized at ER-Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle.Histochemistry and cell biology · 2015Article
- The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.The EMBO journal · 2013Article
- Multi-step down-regulation of the secretory pathway in mitosis: a fresh perspective on protein trafficking.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The structure of the endoplasmic reticulum (ER) undergoes highly regulated changes in specialized cell types. One frequently observed type of change is its reorganization into stacked and concentrically whorled membranes, but the underlying mechanisms and functional relevance for cargo export are unknown. Here, we identify Yip1A, a conserved membrane protein that cycles between the ER and early Golgi, as a key mediator of ER organization. Yip1A depletion led to restructuring of the network into multiple, micrometer-sized concentric whorls. Membrane stacking and whorl formation coincided with a marked slowing of coat protein (COP)II-mediated protein export. Furthermore, whorl formation driven by exogenous expression of an ER protein with no role in COPII function also delayed cargo export. Thus, the slowing of protein export induced by Yip1A depletion may be attributed to a proximal role for Yip1A in regulating ER network dispersal. The ER network dispersal function of Yip1A was blocked by alteration of a single conserved amino acid (E95K) in its N-terminal cytoplasmic domain. These results reveal a conserved Yip1A-mediated mechanism for ER membrane organization that may serve to regulate cargo exit from the organelle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.