Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2010
Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases.
Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Does Measurement of First-Order and Heterogeneity Parameters Improve Response Assessment of Bone Metastases in Breast Cancer Compared to SUVMolecular imaging and biology · 2019Trial
- Prediction of therapy response in bone-predominant metastatic breast cancer: comparison of [European journal of nuclear medicine and molecular imaging · 2019Trial
- Castration-resistant prostate cancer bone metastasis response measured by 18F-fluoride PET after treatment with dasatinib and correlation with progression-free survival: results from American College of Radiology Imaging Network 6687.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Trial
- Imaging of Bone Metastases in Breast Cancer.Seminars in nuclear medicine · 2022Review
- Structural and practical identifiability of dual-input kinetic modeling in dynamic PET of liver inflammation.Physics in medicine and biology · 2019Article
- Is Response Assessment of Breast Cancer Bone Metastases Better with Measurement ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Bone and Calcified Soft Tissue Metastases of Medullary Thyroid Carcinoma Better Characterized onNuclear medicine and molecular imaging · 2018Article
- Functional and Hybrid Imaging of Bone Metastases.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Review
- Site specific measurements of bone formation using [Quantitative imaging in medicine and surgery · 2018Review
- Predictive value of [European journal of nuclear medicine and molecular imaging · 2017Article
- Optimizing an 18F-NaF and 18F-FDG cocktail for PET assessment of metastatic castration-resistant prostate cancer.Nuclear medicine communications · 2015Article
- Characterization of bone perfusion by dynamic contrast-enhanced magnetic resonance imaging and positron emission tomography in the Dunkin-Hartley guinea pig model of advanced osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Comparison of NaF and FDG PET/CT for assessment of treatment response in castration-resistant prostate cancers with osseous metastases.Clinical genitourinary cancer · 2015Article
- Imaging of site specific bone turnover in osteoporosis using positron emission tomography.Current osteoporosis reports · 2014Review
- An Approach to Breast Cancer Diagnosis via PET Imaging of Microcalcifications Using (18)F-NaF.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- Nitric oxide-mediated vasodilation increases blood flow during the early stages of stress fracture healing.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- The isotope bone scan: we can do better.European journal of nuclear medicine and molecular imaging · 2013Article
- Quantification of skeletal blood flow and fluoride metabolism in rats using PET in a pre-clinical stress fracture model.Molecular imaging and biology · 2012Article
- Importance of quantification for the analysis of PET data in oncology: review of current methods and trends for the future.Molecular imaging and biology · 2012Review
- Advances in molecular imaging for breast cancer detection and characterization.Breast cancer research : BCR · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledThe most common site of metastasis for breast cancer is bone. Quantitative (18)F-fluoride PET can estimate the kinetics of fluoride incorporation into bone as a measure of fluoride transport, bone formation, and turnover. The purpose of this analysis was to evaluate the accuracy and precision of (18)F-fluoride model parameter estimates for characterizing regional kinetics in metastases and normal bone in breast cancer patients.
methodsTwenty metastatic breast cancer patients underwent dynamic (18)F-fluoride PET. Mean activity concentrations were measured from serial blood samples and regions of interest placed over bone metastases, normal vertebrae, and cardiac blood pools. This study examined parameter identifiability, model sensitivity, error, and accuracy using parametric values from the patient cohort.
resultsRepresentative time-activity curves and model parameter ranges were obtained from the patient cohort. Model behavior analyses of these data indicated (18)F-fluoride transport and flux (K(1) and Ki, respectively) into metastatic and normal osseous tissue could be independently estimated with a reasonable bias of 9% or less and reasonable precision (coefficients of variation <or= 16%). Average (18)F-fluoride transport and flux into metastases from 20 patients (K(1) = 0.17 +/- 0.08 mL x cm(-3) x min(-1) and Ki = 0.10 +/- 0.05 mL x cm(-3) x min(-1)) were both significantly higher than for normal bone (K(1) = 0.09 +/- 0.03 mL x cm(-3) x min(-1) and Ki = 0.05 +/- 0.02 mL x cm(-3) x min(-1), P < 0.001).
conclusionFluoride transport and flux can be accurately and independently estimated for bone metastases and normal vertebrae. Reasonable bias and precision for estimates of K(1) and Ki from simulations and significant differences in values from patient modeling results in metastases and normal bone suggest that (18)F-fluoride PET images may be useful for assessing changes in bone turnover in response to therapy. Future studies will examine the correlation of parameters to biologic features of bone metastases and to response to therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.