ArticleProstaglandins, leukotrienes, and essential fatty acids
Alternative transcripts of fatty acid desaturase (FADS) genes.
Article in Prostaglandins, leukotrienes, and essential fatty acids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.Nutrition reviews · 2020Pooled it
- NSCLC Cells Resistance to PI3K/mTOR Inhibitors Is Mediated by Delta-6 Fatty Acid Desaturase (FADS2).Cells · 2022Article
- Maternal and child fatty acid desaturase genotype as determinants of cord blood long-chain PUFA (LCPUFA) concentrations in the Seychelles Child Development Study.The British journal of nutrition · 2021Article
- Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19Prostaglandins, leukotrienes, and essential fatty acids · 2020Review
- FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome.The Journal of biological chemistry · 2020Article
- Article
- Dietary pattern regulates fatty acid desaturase 1 gene expression in Indian pregnant women to spare overall long chain polyunsaturated fatty acids levels.Molecular biology reports · 2019Article
- A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Δ6-desaturation of omega-3 fatty acids.Prostaglandins, leukotrienes, and essential fatty acids · 2018Article
- Fads3 modulates docosahexaenoic acid in liver and brain.Prostaglandins, leukotrienes, and essential fatty acids · 2017Article
- Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells.Journal of lipid research · 2017Article
- Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis.Current opinion in clinical nutrition and metabolic care · 2016Review
- DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide risk.Frontiers in neurology · 2015Article
- Trans-vaccenate is Δ13-desaturated by FADS3 in rodents.Journal of lipid research · 2013Article
- Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets.Prostaglandins, leukotrienes, and essential fatty acids · 2013Article
- Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts.Prostaglandins, leukotrienes, and essential fatty acids · 2013Article
- A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.Journal of lipid research · 2012Article
- Article
- The polypyrimidine tract binding protein regulates desaturase alternative splicing and PUFA composition.Journal of lipid research · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Alternative splicing is a major mechanism for increasing the range of products encoded by the genome. We recently reported positive identification of the first alternative transcripts (AT) of fatty acid desaturase 3 (FADS3) and FADS2 in fetal and neonatal baboons. FADS3, a putative polyunsaturated fatty acid (PUFA) desaturase gene with no known function, has 7 AT that are expressed in at least twelve organs in an apparently constitutive manner. At least five of seven AT are expressed in several mammals and the chicken. FADS2, catalyzing 6 and 8 desaturation and having multiple PUFA substrates, has one AT that is missing two exons and portions of two others. Semi-quantitative expression estimates reveal at least 20-fold differential expression of FADS2 AT1 among neonatal baboon organs compared to 2-fold in the same organs for the classically spliced (CS) FADS2 transcript. Expression of four of the FADS3 AT, those with missing putatively active domains, is highly correlated among organs, suggesting coordinated coexpression. AT may serve as templates to generate protein isoforms or as signaling molecules, and their widespread detection and expression patterns suggest that they play an important role in PUFA biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.