SynthesisDrug and alcohol dependence2010
The more you drink, the harder you fall: a systematic review and meta-analysis of how acute alcohol consumption and injury or collision risk increase together.
Synthesis in Drug and alcohol dependence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03867812 (Effect of Consumption of Different Foods on the Pharmacokinetics of a Small Dose of Ethanol), which is not on this map. Cited by 197 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Consumption of Different Foods on the Pharmacokinetics of a Small Dose of Ethanol: A Randomized Controlled, Clinical Trial in Healthy Individuals
Who cites it
197 citing papers in PubMed, 7 syntheses or guidelines pooled it, 491 citations in OpenAlex.
- Alcohol consumption among university students in Ethiopia: a systematic review and meta-analysis of epidemiological studies.Frontiers in public health · 2025Pooled it
- Alcohol Consumption and 15 Causes of Fatal Injuries: A Systematic Review and Meta-Analysis.American journal of preventive medicine · 2022Pooled it
- Mobile Health Interventions for Self-Control of Unhealthy Alcohol Use: Systematic Review.JMIR mHealth and uHealth · 2019Pooled it
- The relationship between different dimensions of alcohol use and the burden of disease-an update.Addiction (Abingdon, England) · 2017Pooled it
- Alcohol consumption for simulated driving performance: A systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2017Pooled it
- A systematic review and meta-analysis of alcohol consumption and injury risk as a function of study design and recall period.Alcoholism, clinical and experimental research · 2013Pooled it
- The relationship between alcohol consumption and fatal motor vehicle injury: high risk at low alcohol levels.Alcoholism, clinical and experimental research · 2012Pooled it
- Effect of alcohol coadministration on the pharmacodynamics, pharmacokinetics, and safety of lemborexant: A randomized, placebo-controlled crossover study.Journal of psychopharmacology (Oxford, England) · 2022Trial
- Effect of a Snack Bar Optimized to Reduce Alcohol Bioavailability: A Randomized Controlled Clinical Trial in Healthy Individuals.Journal of medicinal food · 2020Trial
- Perspectives in Implementing a Primary Care-Based Intervention to Reduce Alcohol Misuse.American journal of preventive medicine · 2015Trial
- Differences in risk of injury in the U.S. general population by injury treatment type: data from the 1995 to 2010 national alcohol surveys.Alcoholism, clinical and experimental research · 2014Trial
- Risk factors for alcohol-related injury experienced within a year: results of a nationwide large-scale internet survey.Addictive behaviors reports · 2026Article
- Alcohol use is common in older patients with fall-related fractures: a secondary analysis from a prospective cohort study using PEth as an objective assessment of consumption.Acta orthopaedica · 2026Observational
- Health risks of alcohol consumption in Aotearoa New Zealand: modelling to inform low-risk-drinking guidelines.International journal of epidemiology · 2026Article
- Orthopaedic Trauma in Patients with Documented Alcohol Use: Injury Mechanisms, Clinical Characteristics, and Geriatric Vulnerability.Medical sciences (Basel, Switzerland) · 2026Article
- Impact of Moderate Wine Consumption on Type 2 Diabetes.Nutrients · 2026Review
- Role of socioeconomic status in modifying the relationship between alcohol use and injury events: evidence from the UK Biobank.Journal of epidemiology and community health · 2026Article
- Exploring resiliencies to housing eviction and alcohol-related harms: A photo elicitation study.Wellbeing, space and society · 2026Article
- A randomised, double-blind, placebo-controlled trial examining the dose-dependent effects of acute alcohol intoxication on neurocognitive performance.Psychopharmacology · 2026Article
- From drivers to passengers: concept of passive drink driving and need for passenger-centric interventions to reduce drink-driving in Bengaluru City, India.BMC public health · 2026Article
137 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 6 countries.
Funding
Abstract
Alcohol consumption causes injury in a dose-response manner. The most common mode of sustaining an alcohol-attributable injury is from a single occasion of acute alcohol consumption, but much of the injury literature employs usual consumption habits to assess risk instead. An analysis of the acute dose-response relationship between alcohol and injury is warranted to generate single occasion- and dose-specific relative risks. A systematic literature review and meta-analysis was conducted to fill this gap. Linear and best-fit first-order model were used to model the data. Usual tests of heterogeneity and publication bias were run. Separate meta-analyses were run for motor vehicle and non-motor vehicle injuries, as well as case-control and case-crossover studies. The risk of injury increases non-linearly with increasing alcohol consumption. For motor vehicle accidents, the odds ratio increases by 1.24 (95% CI: 1.18-1.31) per 10-g in pure alcohol increase to 52.0 (95% CI: 34.50-78.28) at 120 g. For non-motor vehicle injury, the OR increases by 1.30 (95% CI: 1.26-1.34) to an OR of 24.2 at 140 g (95% CI: 16.2-36.2). Case-crossover studies of non-MVA injury result in overall higher risks than case-control studies and the per-drink increase in odds of injury was highest for intentional injury, at 1.38 (95% CI: 1.22-1.55). Efforts to reduce drinking both on an individual level and a population level are important. No level of consumption is safe when driving and less than 2 drinks per occasion should be encouraged to reduce the risk of injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.