ReviewJournal of reproductive immunology2010
Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design.
Review in Journal of reproductive immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Trial
- Review
- Article
- Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract.Mucosal immunology · 2021Article
- New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes.NPJ vaccines · 2020Article
- Evaluation of Mucosal Humoral and Cellular Immune Responses to HIV in External Secretions and Mucosal Tissues.Current immunology reviews · 2019Article
- A review of the human vs. porcine female genital tract and associated immune system in the perspective of using minipigs as a model of human genital Chlamydia infection.Veterinary research · 2015Review
- Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Human papillomavirus antibodies and future risk of anogenital cancer: a nested case-control study in the European prospective investigation into cancer and nutrition study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Humoral immune responses to HIV in the mucosal secretions and sera of HIV-infected women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- An attenuated duck plague virus (DPV) vaccine induces both systemic and mucosal immune responses to protect ducks against virulent DPV infection.Clinical and vaccine immunology : CVI · 2014Article
- Article
- Article
- Mucosal immunology of HIV infection.Immunological reviews · 2013Review
- Developing multipurpose reproductive health technologies: an integrated strategy.AIDS research and treatment · 2013Article
- Understanding and learning from the success of prophylactic human papillomavirus vaccines.Nature reviews. Microbiology · 2012Review
- Controlling the HIV/AIDS epidemic: current status and global challenges.Frontiers in immunology · 2012Article
- Detection of Mycoplasma genitalium-reactive cervicovaginal antibodies among infected women.Clinical and vaccine immunology : CVI · 2011Article
- A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection.Journal of virology · 2011Article
- Methods for evaluation of humoral immune responses in human genital tract secretions.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mucosal tissues of the genital tracts and the distal intestinal tract are portals of entry for infectious agents of sexually transmitted diseases, including HIV-1. Although the genital and intestinal tracts share a common embryologic origin and remain in anatomical proximity, these two sites display remarkably different immunologic features, including the levels, isotypes and molecular forms of immunoglobulins, and magnitudes and qualities of humoral and cellular immune responses. Thus, viral and bacterial infections of the genital tract or intravaginal immunizations induce, in the absence of mucosal adjuvants, minimal immune responses. Consequently, to induce relevant immune responses in the genital tract, alternative immunization routes have been explored, including systemic, intranasal, oral, or rectal immunization and their combinations. In limited studies performed in animals, systemic immunization with a subsequent mucosal (intranasal) immunization proved to be effective in the induction of humoral immune responses in genital tract secretions. The approaches have been explored to a limited extent in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.