Trial reportEuropean journal of neurology2010
Caudate atrophy on MRI is a characteristic feature of FTLD-FUS.
Trial report in European journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 115 citations in OpenAlex.
- Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects.Metabolites · 2025Article
- Diagnostic utility of brain MRI volumetry in comparing traumatic brain injury, Alzheimer disease and behavioral variant frontotemporal dementia.BMC neurology · 2024Article
- Patterns of glucose hypometabolism can help differentiate FTLD-FET from other types of FTLD.Journal of neurology · 2024Article
- Neuroimaging-guided diagnosis of possible FTLD-FUS pathology: a case report.EJNMMI research · 2024Article
- Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations.Disease models & mechanisms · 2023Article
- A presumptive association between obsessive compulsions and asymmetric temporal lobe atrophy: a case report.Journal of medical case reports · 2022Article
- Recurrent Facial Focal Seizures With Chronic Striatopathy and Caudate Atrophy-A Double Whammy in an Elderly Woman With Diabetes Mellitus.The Neurohospitalist · 2022Article
- Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.Molecular neurodegeneration · 2021Article
- Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.Nature communications · 2021Article
- Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits.Acta neuropathologica communications · 2021Article
- Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia.Brain communications · 2021Review
- Neuronal intermediate filament inclusion disease may be incorrectly classified as a subtype of FTLD-FUS.Free neuropathology · 2020Article
- Tauopathy and Movement Disorders-Unveiling the Chameleons and Mimics.Frontiers in neurology · 2020Review
- FTD spectrum: Neuroimaging across the FTD spectrum.Progress in molecular biology and translational science · 2019Review
- Clinicopathological correlations in behavioural variant frontotemporal dementia.Brain : a journal of neurology · 2017Article
- Caudate nucleus as a component of networks controlling behavior.Neurology · 2017Article
- Frontotemporal lobar degeneration: Pathogenesis, pathology and pathways to phenotype.Brain pathology (Zurich, Switzerland) · 2017Review
- Neuroimaging in Dementia.Seminars in neurology · 2017Review
- Imaging and fluid biomarkers in frontotemporal dementia.Nature reviews. Neurology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeFrontotemporal lobar degeneration (FTLD) can be subdivided into those in which the abnormal protein is tau (FTLD-TAU), the TAR DNA binding protein 43 (FTLD-TDP) and the fused in sarcoma protein (FTLD-FUS). We have observed severe caudate atrophy at autopsy in FTLD-FUS, and hence, we aimed to determine whether caudate atrophy on MRI is a feature that can distinguish FTLD-FUS from FTLD-TDP and FTLD-TAU.
methodsFrom a cohort of 207 cases of FTLD, we identified all cases of FTLD-FUS that had a volumetric antemortem head MRI (n = 3). Caudate and frontal lobe volumes were measured in all three cases using atlas-based parcellation and SPM5 and were compared to 10 randomly selected cases of FTLD-TDP and 10 randomly selected cases of FTLD-TAU. Total grey matter volumes were also calculated for all cases.
resultsThe FTLD-FUS cases had significantly smaller caudate volumes (P = 0.02) yet similar frontal lobe grey matter volumes (P = 0.12) compared to FTLD-TDP and FTLD-TAU. Caudate volumes when corrected for total grey matter volume (P = 0.01) or frontal lobe grey matter volume (P = 0.01) were significantly smaller in FTLD-FUS than in FTLD-TDP and FTLD-TAU and showed no overlap with the other two groups.
conclusionsCaudate atrophy on MRI appears to be significantly greater in FTLD-FUS compared with FTLD-TDP and FTLD-TAU, suggesting that severe caudate atrophy may be a useful clinical feature to predict FTLD-FUS pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.