ReviewLymphatic research and biology2010
Lymphangioleiomyomatosis and TSC2-/- cells.
Review in Lymphatic research and biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Exploring the uncharted role of cell senescence in rare diseases.Orphanet journal of rare diseases · 2025Review
- An Evidence-Based Update on the Potential Association between Rheumatoid Arthritis and Lymphangioleiomyomatosis.Journal of personalized medicine · 2023Review
- Long-Term Effects of Sirolimus on Human Skin TSC2-Null Fibroblast‒Like Cells.The Journal of investigative dermatology · 2021Article
- Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis.Molecular cell · 2021Article
- High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial Neoplasia.International journal of molecular sciences · 2020Review
- Article
- Thoracoabdominal imaging of tuberous sclerosis.Pediatric radiology · 2018Review
- Human Pluripotent Stem Cell-DerivedCancer research · 2017Article
- Leiomyoma and leiomyoma cellulare of the fallopian tube: review of the literature and case reports.Przeglad menopauzalny = Menopause review · 2016Article
- Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2(-) Tumor Related to Lymphangioleiomyomatosis.The American journal of pathology · 2016Article
- Doxycycline reduces the migration of tuberous sclerosis complex-2 null cells - effects on RhoA-GTPase and focal adhesion kinase.Journal of cellular and molecular medicine · 2015Article
- Sex-specific lung diseases: effect of oestrogen on cultured cells and in animal models.European respiratory review : an official journal of the European Respiratory Society · 2013Review
- Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene.The American journal of pathology · 2013Article
- Targeted approaches toward understanding and treating pulmonary lymphangioleiomyomatosis (LAM).Hormones & cancer · 2013Review
- Treatment option(s) for pulmonary lymphangioleiomyomatosis: progress and current challenges.American journal of respiratory cell and molecular biology · 2012Article
- The new era of the lymphatic system: no longer secondary to the blood vascular system.Cold Spring Harbor perspectives in medicine · 2012Review
- Article
- Frequency of undiagnosed cystic lung disease in patients with sporadic renal angiomyolipomas.Chest · 2012Article
- Diagnostic value of serum vascular endothelial growth factor-D in Korean patients with lymphangioleiomyomatosis.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The cells comprising pulmonary lymphangioleiomyomatosis (LAM) and renal angiomyolipomas (AMLs) are heterogeneous, with variable mixtures of cells exhibiting differentiation towards smooth muscle, fat, and vessels. Cells grown from LAM and AMLs have likewise tended to be heterogeneous. The discovery that LAM and AMLs contain cells with mutations in the TSC1 or TSC2 genes is allowing investigators to discriminate between "two-hit" cells and neighboring cells, providing insights into disease pathogenesis. In rare cases, it has been possible to derive cells from human tumors, including AMLs and TSC skin tumors that are highly enriched for TSC2(-/-) cells. Cells derived from an Eker rat uterine leiomyoma (ELT3 cells) are Tsc2-null and these have been used in a rodent cell models for LAM. Further improvements in the ability to reliably grow well-characterized TSC2(-/-) cells from human tumors are critical to developing in vitro and in vivo model systems for studies of LAM pathogenesis and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.