Evidence map›Paper›PMID 20235235›Full record

ReviewCytometry. Part A : the journal of the International Society for Analytical Cytology2010

Cytometry in cell necrobiology revisited. Recent advances and new vistas.

Donald Wlodkowic, Joanna Skommer, Zbigniew Darzynkiewicz

Abstract readReview
In one paragraph

Review in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
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  4. Review
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  9. Article
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  11. Article
  12. Flow Cytometry Reveals the Nature of Oncotic Cells.International journal of molecular sciences · 2019
    Article
  13. Synthesis and In Vitro Antitumor Activity of Novel BivalentInternational journal of molecular sciences · 2018
    Article
  14. The cucurbitacins D, E, and I fromIranian journal of basic medical sciences · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2013
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Donald WlodkowicThe Bioelectronics Research Centre, University of Glasgow, Glasgow, United Kingdom. d.wlodkowic@elec.gla.ac.uk
Joanna Skommer
Zbigniew Darzynkiewicz
University of Auckland · NZ

Funding

PROBES FOR FLOW CYTOMETRYR01CA028704 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI DARZYNKIEWICZ, ZBIGNIEW · 1985 to 2014
$6.0M
NCI NIH HHS R01 CA028704
6 · The paper itself

Abstract

Over a decade has passed since publication of the last review on "Cytometry in cell necrobiology." During these years we have witnessed many substantial developments in the field of cell necrobiology such as remarkable advancements in cytometric technologies and improvements in analytical biochemistry. The latest innovative platforms such as laser scanning cytometry, multispectral imaging cytometry, spectroscopic cytometry, and microfluidic Lab-on-a-Chip solutions rapidly emerge as highly advantageous tools in cell necrobiology studies. Furthermore, we have recently gained substantial knowledge on alternative cell demise modes such as caspase-independent apoptosis-like programmed cell death (PCD), autophagy, necrosis-like PCD, or mitotic catastrophe, all with profound connotations to pathogenesis and treatment. Although detection of classical, caspase-dependent apoptosis is still the major ground for the advancement of cytometric techniques, there is an increasing demand for novel analytical tools to rapidly quantify noncanonical modes of cell death. This review highlights the key developments warranting a renaissance and evolution of cytometric techniques in the field of cell necrobiology.

Indexed as

Cytological TechniquesFlow CytometryImage CytometryApoptosisBiomarkersCaspasesCell DeathCell MembraneEnzyme ActivationHistonesHumansMicrofluidic Analytical TechniquesBiomarkersCaspasesHistones

Identifiers

PMID20235235
PMCPMC2975392
OpenAlexW2040342258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.