Evidence map›Paper›PMID 20234846›Full record

ArticleProgress in polymer science2007

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders.

A V Kabanov, H E Gendelman

Abstract read
In one paragraph

Article in Progress in polymer science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 269 citations in OpenAlex.

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  14. Carbon quantum dots in bioimaging and biomedicines.Frontiers in bioengineering and biotechnology · 2023
    Review
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

A V KabanovDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
H E Gendelman
University of Nebraska Medical Center · US

Funding

VIRAL SHUTOFF OF HOST TRANSCRIPTION--PBCV-1 INFECTEDP20RR015635 · NCRR · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2000 to 2009
$22.1M
Immunopathogenesis of HIV Neurological DisordersU54NS043011 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI KRAISELBURD, EDMUNDO NELSON · 2001 to 2011
$14.6M
Neuroprotective Immunity and HIV DementiaR01NS034239 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Howard E Gendelman, R Lee Mosley · 1995 to 2026
$12.3M
Proteomics CoreP01NS043985 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHENG, JIALIN CHARLES · 2003 to 2012
$11.8M
Role of EAAT2 and AEG-1 in Astrocyte Dysfunction and NeurodegenerationP01NS031492 · NINDS · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI GELBARD, HARRIS A · 1993 to 2007
$10.9M
Polypeptide Modification for Enhanced Brain DeliveryR01NS051334 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BANKS, WILLIAM A, KABANOV, ALEXANDER V · 2006 to 2014
$2.7M
Blood Brain Barrier Physiology and HIV DementiaR37NS036126 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E. · 2001 to 2007
$2.7M
Pluronic Block Copolymers in Drug Resistant CancerR01CA089225 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KABANOV, ALEXANDER V · 2001 to 2011
$2.2M
INTERACTIONS OF BLOCK COPOLYMERS IN BLOOD BRAIN BARRIERSR01NS036229 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KABANOV, ALEXANDER V · 1997 to 2006
$1.9M
Polymer Based Gene DeliveryR01CA116591 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KABANOV, ALEXANDER V · 2006 to 2010
$1.3M
NCI NIH HHS R01 CA089225NCI NIH HHS R01 CA116591NCRR NIH HHS P20 RR015635NINDS NIH HHS P01 NS031492NINDS NIH HHS P01 NS043985NINDS NIH HHS R01 NS034239NINDS NIH HHS R01 NS036229NINDS NIH HHS R01 NS051334NINDS NIH HHS R37 NS036126NINDS NIH HHS U54 NS043011
6 · The paper itself

Abstract

Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population's age. Alzheimer's disease alone currently affects 4.5 million Americans, and more than $100 billion is spent per year on medical and institutional care for affected people. Such numbers will double in the ensuing decades. Currently disease diagnosis for all disorders is made, in large measure, on clinical grounds as laboratory and neuroimaging tests confirm what is seen by more routine examination. Achieving early diagnosis would enable improved disease outcomes. Drugs, vaccines or regenerative proteins present "real" possibilities for positively affecting disease outcomes, but are limited in that their entry into the brain is commonly restricted across the blood-brain barrier. This review highlights how these obstacles can be overcome by polymer science and nanotechnology. Such approaches may improve diagnostic and therapeutic outcomes. New developments in polymer science coupled with cell-based delivery strategies support the notion that diseases that now have limited therapeutic options can show improved outcomes by advances in nanomedicine.

Identifiers

PMID20234846
PMCPMC2838200
OpenAlexW1970780136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.