ArticleEuropean journal of human genetics : EJHG2010
Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.European urology · 2014Pooled it
- Knowledge integration in cancer: current landscape and future prospects.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Pooled it
- Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.Hypertension (Dallas, Tex. : 1979) · 2011Pooled it
- BaGPipe: an automated, reproducible, and flexible pipeline for bacterial genome-wide association studies.BMC microbiology · 2026Article
- Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study.Nature communications · 2025Article
- Identification of quantitative trait loci and associated candidate genes for pregnancy success in Angus-Brahman crossbred heifers.Journal of animal science and biotechnology · 2023Article
- Open Science 2.0: Towards a truly collaborative research ecosystem.PLoS biology · 2023Article
- Article
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- 100 YEARS OF INSULIN: A brief history of diabetes genetics: insights for pancreatic beta-cell development and function.The Journal of endocrinology · 2021Review
- Three genes associated with anterior and posterior cruciate ligament injury : a genome-wide association analysis.Bone & joint open · 2021Article
- The Burden of Antipsychotic-Induced Weight Gain and Metabolic Syndrome in Children.Frontiers in psychiatry · 2021Review
- Two GWAS-identified variants are associated with lumbar spinal stenosis and Gasdermin-C expression in Chinese population.Scientific reports · 2020Article
- Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda.Annals of global health · 2020Review
- Why is Disease Penetration So Variable? Role of Genetic Modifiers of Lung Function in Alpha-1 Antitrypsin Deficiency.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2020Review
- Sources of bias in genomics research of oral and dental traits.Community dental health · 2020Review
- Using genomic profiling for understanding and improving response to smoking cessation treatment.Current epidemiology reports · 2019Article
- Beyond the One Gene-One Disease Paradigm: Complex Genetics and Pleiotropy in Inheritable Cardiac DisordersCirculation · 2019Review
- Genome-wide association study (GWAS) of human host factors influencing viral severity of herpes simplex virus type 2 (HSV-2).Genes and immunity · 2019Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies (GWASs) have created a paradigm shift in discovering genetic associations for common diseases and phenotypes, but it is unclear whether the thousands of candidate genetic association studies performed in the pre-GWAS era had found any reliable associations for common diseases and phenotypes. We aimed to systematically evaluate whether loci proposed to harbor candidate associations before the advent of GWASs are replicated in GWASs. The GWAS data published through August, 2008 and included in the NHGRI catalog were screened and variants in candidate loci were selected on the basis of statistical significance (P<0.05) to create a list of independent, non-redundant associations. Altogether, 159 articles on GWASs were evaluated, 100 of which addressed past proposed candidate loci. A total of 291 independent, nominally significant (P<0.05) candidate gene associations were assembled after keeping only the SNP with lowest P-value for each locus and each phenotype; 108 of those had P<10(-3) for association and 41 had P<10(-7). A total of 22 of these 41 candidate gene associations pertained to binary phenotypes with a median odds ratio=2.91 (IQR: 1.82-4.6) and median minor allele frequency=0.17 (IQR: 0.12-0.29) in Caucasians; for comparison, 60 new associations of binary outcomes with P<10(-7) discovered in the same GWASs had much smaller effects (median odds ratio 1.30, IQR: 1.18-1.58) and modestly larger minor allele frequencies (median 0.27, IQR: 0.15-0.43). Overall, few of the numerous genetic associations proposed in the candidate gene era have been replicated in GWASs, but those that have been conclusively replicated have large genetic effects that should not be discarded.
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