Evidence map›Paper›PMID 20233982›Full record

Trial reportCirculation. Cardiovascular quality and outcomes2010

Rationale and design of the Pharmacist Intervention for Low Literacy in Cardiovascular Disease (PILL-CVD) study.

Jeffrey L Schnipper, Christianne L Roumie, Courtney Cawthon, Alexandra Businger, Anuj K Dalal, Ileko Mugalla, Svetlana Eden, Terry A Jacobson, Kimberly J Rask, Viola Vaccarino and 7 more

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Circulation. Cardiovascular quality and outcomes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00632021 nacompletednot on this map

Pharmacist Intervention for Low-Literacy in Cardiovascular Disease

TypeinterventionalSponsorVanderbilt University Medical CenterRan2008 to 2012Enrolled862ConditionsAcute Coronary Syndrome, Heart FailureArmsPharmacist Intervention for Low-Literacy in Cardiovascular Disease
NCT01337063 nacompletednot on this mapstarted 2011, after this paper: background citation

Multi-Center Medication Reconciliation Quality Improvement Study

TypeinterventionalSponsorBrigham and Women's HospitalRan2011 to 2014Enrolled1,836ConditionsAdverse Drug Events, Medication Administered in ErrorArmsMentored medication reconciliation quality improvement
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Discharge planning from hospital.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Pooled it
  3. Discharge planning from hospital.The Cochrane database of systematic reviews · 2016
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Improving care transitions: the patient perspective.Journal of health communication · 2012
    Trial
  10. Trial
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Observational
  18. Article
  19. Article
  20. The Hospital Medicine Reengineering Network (HOMERuN): a learning organization focused on improving hospital care.Academic medicine : journal of the Association of American Medical Colleges · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Jeffrey L SchnipperDivision of General Medicine and Primary Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Christianne L Roumie
Courtney Cawthon
Alexandra Businger
Anuj K Dalal
Ileko Mugalla
Svetlana Eden
Terry A Jacobson
Kimberly J Rask
Viola Vaccarino
Tejal K Gandhi
David W Bates
Daniel C Johnson
Stephanie Labonville
David Gregory
Sunil Kripalani
PILL-CVD Study Group
Harvard University · USGeriatric Research Education and Clinical Center · USEmory University · USTarget (United States) · USVanderbilt University · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Pharmacist Intervention for Low Literacy in Cardiovascular Disease (PILL-CVD)R01HL089755 · NHLBI · VANDERBILT UNIVERSITY · PI KRIPALANI, SUNIL · 2007 to 2009
$1.8M
Using Information Systems to Improve Cardiac PreventionK08HL072806 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHNIPPER, JEFFREY LAWRENCE · 2003 to 2007
$669k
Training in Medication Compliance and Health LiteracyK23HL077597 · NHLBI · VANDERBILT UNIVERSITY · PI KRIPALANI, SUNIL · 2004 to 2008
$636k
NCATS NIH HHS UL1 TR000454NHLBI NIH HHS K08 HL072806NHLBI NIH HHS K23 HL077597NHLBI NIH HHS R01 HL089755
6 · The paper itself

Abstract

backgroundMedication errors and adverse drug events are common after hospital discharge due to changes in medication regimens, suboptimal discharge instructions, and prolonged time to follow-up. Pharmacist-based interventions may be effective in promoting the safe and effective use of medications, especially among high-risk patients such as those with low health literacy. METHODS AND

resultsThe Pharmacist Intervention for Low Literacy in Cardiovascular Disease (PILL-CVD) study is a randomized controlled trial conducted at 2 academic centers-Vanderbilt University Hospital and Brigham and Women's Hospital. Patients admitted with acute coronary syndrome or acute decompensated heart failure were randomly assigned to usual care or intervention. The intervention consisted of pharmacist-assisted medication reconciliation, inpatient pharmacist counseling, low-literacy adherence aids, and tailored telephone follow-up after discharge. The primary outcome is the occurrence of serious medication errors in the first 30 days after hospital discharge. Secondary outcomes are health care utilization, disease-specific quality of life, and cost-effectiveness. Enrollment was completed September 2009. A total of 862 patients were enrolled, and 430 patients were randomly assigned to receive the intervention. Analyses will determine whether the intervention was effective in reducing serious medication errors, particularly in patients with low health literacy.

conclusionsThe PILL-CVD study was designed to reduce serious medication errors after hospitalization through a pharmacist-based intervention. The intervention, if effective, will inform health care facilities on the use of pharmacist-assisted medication reconciliation, inpatient counseling, low-literacy adherence aids, and patient follow-up after discharge. Clinical Trial Registration- clinicaltrials.gov. Identifier: NCT00632021.

Indexed as

Health Knowledge, Attitudes, PracticePatient Education as TopicPharmacistsProfessional RoleResearch DesignAcademic Medical CentersAcute Coronary SyndromeCardiovascular AgentsCost-Benefit AnalysisCounselingDelivery of Health CareDrug InteractionsEducational StatusHealth Care CostsHeart FailureHumansCardiovascular Agents

Identifiers

PMID20233982
PMCPMC3021350
OpenAlexW2113209673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.