ArticleEndocrinology2010
The ontogeny of insulin signaling in the preterm baboon model.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Risk of hypertension following perinatal adversity: IUGR and prematurity.The Journal of endocrinology · 2019Review
- Article
- Adipose and Liver Function in Primate Offspring with Insulin Resistance Induced by Estrogen Deprivation in Utero.Endocrinology, diabetes and metabolism journal · 2017Article
- Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons.Endocrinology · 2017Article
- Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring.The Journal of endocrinology · 2016Article
- Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle.Endocrinology · 2016Article
- Cord Blood Levels of Insulin, Cortisol and HOMA2-IR in Very Preterm, Late Preterm and Term Newborns.Journal of clinical and diagnostic research : JCDR · 2016Article
- Peripheral insulin resistance and impaired insulin signaling contribute to abnormal glucose metabolism in preterm baboons.Endocrinology · 2015Article
- Developmental regulation of key gluconeogenic molecules in nonhuman primates.Physiological reports · 2014Article
- Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle.The Journal of endocrinology · 2014Article
- Liver disease after intensive care of premature baboons: histopathologic observations.Journal of pediatric gastroenterology and nutrition · 2013Article
- Hyperglycemia increases the risk of death in extremely preterm baboons.Pediatric research · 2013Article
- Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- The ontogeny of the endocrine pancreas in the fetal/newborn baboon.The Journal of endocrinology · 2012Article
- Ontogeny of proteolytic signaling and antioxidant capacity in fetal and neonatal diaphragm.Anatomical record (Hoboken, N.J. : 2007) · 2012Article
- Effects of cortisol and dexamethasone on insulin signalling pathways in skeletal muscle of the ovine fetus during late gestation.PloS one · 2012Article
- Developmental programming: differential effects of prenatal testosterone excess on insulin target tissues.Endocrinology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Hyperglycemia, a prevalent condition in premature infants, is thought to be a consequence of incomplete suppression of endogenous glucose production and reduced insulin-stimulated glucose disposal in peripheral tissues. However, the molecular basis for these conditions remains unclear. To test the hypothesis that the insulin transduction pathway is underdeveloped with prematurity, fetal baboons were delivered, anesthetized, and euthanized at 125 d gestational age (GA), 140 d GA, or near term at 175 d GA. Vastus lateralis muscle and liver tissues were obtained, and protein content of insulin signaling molecules [insulin receptor (IR)-beta, IR substate-1, p85 subunit of phosphatidylinositol 3-kinase, Akt, and AS160] and glucose transporters (GLUT)-1 and GLUT4 was measured by Western blotting. Muscle from 125 d GA baboons had markedly reduced GLUT1 protein content (16% of 140 d GA and 9% of 175 d GA fetuses). GLUT4 and AS160 also were severely reduced in 125 d GA fetal muscle (43% of 175 d GA and 35% of 175 d GA, respectively). In contrast, the protein content of IR-beta, IR substate-1, and Akt was elevated by 1.7-, 5.2-, and 1.9-fold, respectively, in muscle from 125 d GA baboons when compared with 175 d GA fetuses. No differences were found in the content of insulin signaling proteins in liver. In conclusion, significant gestational differences exist in the protein content of several insulin signaling proteins in the muscle of fetal baboons. Reduced muscle content of key glucose transport-regulating proteins (GLUT1, GLUT4, AS160) could play a role in the pathogenesis of neonatal hyperglycemia and reduced insulin-stimulated glucose disposal.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.