ArticleJournal of medical case reports2010
Primary vaginal Ewing's sarcoma or primitive neuroectodermal tumor in a 17-year-old woman: a case report.
Article in Journal of medical case reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Primary pelvic extraskeletal Ewing sarcoma: a case report and comprehensive literature review of molecularly confirmed cases arising within the female genital tract.Gynecologic oncology reports · 2026Article
- An Unusual Case of a Vulva Tumor in an Adolescent: A Case Report and Literature Review.Acta medica Lituanica · 2026Article
- Primary Endometrium Primitive Neuroectodermal Tumor with Diagnostic and Treatment Challenges: A Case Report.International journal of women's health · 2026Article
- An unusual presentation of extraskeletal vaginal Ewing sarcoma: A case report.Case reports in women's health · 2023Article
- Importance of studying primitive neuroectodermal tumors and extraosseous Ewings sarcoma of the vagina and vulva.Oncology letters · 2021Review
- Article
- Primitive Neuroectodermal Tumors of the Female Genital Tract: A Morphologic, Immunohistochemical, and Molecular Study of 19 Cases.The American journal of surgical pathology · 2017Article
- Vaginal Ewing Sarcoma: An Uncommon Clinical Entity in Pediatric Patients.Journal of clinical imaging science · 2017Article
- Primary Vaginal Ewing's sarcoma: A Rare Case Report.Journal of obstetrics and gynaecology of India · 2016Article
- Primitive Neuroectodermal Tumor of the Vulva in an Adolescent Girl.World journal of oncology · 2014Article
- Clinicopathological and molecular spectrum of ewing sarcomas/PNETs, including validation of EWSR1 rearrangement by conventional and array FISH technique in certain cases.Pathology oncology research : POR · 2014Article
- Primitive neuroectodermal tumor of ovary in a young lady, confirmed with molecular and cytogenetic results--a rare case report with a diagnostic and therapeutic challenge.Pathology oncology research : POR · 2012Article
- Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade's Experience From a Single Centre in India.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Article
- Extraosseous Ewing sarcoma of the vagina: a rare entity.Annals of Saudi medicineReview
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrimary Ewing's sarcoma or primitive neuroectodermal tumor of the genital tract of women is uncommon. Rarer still is its occurrence in the vagina, with only five cases described so far. Out of these, only one case was confirmed using molecular analysis. CASE PRESENTATION: We present an extremely rare case of Ewing's sarcoma or primitive neuroectodermal tumor in a 17-year-old Indian girl. She presented with a vaginal mass that was initially diagnosed as a malignant round cell tumor. Immunohistochemistry showed diffuse positivity for vimentin, membranous positivity for MIC2, and positivity for BCL2 and FLI-1. On the other hand, she was negative for cytokeratin, epithelial membrane antigen, desmin, Myo D-1, myogenin and smooth muscle actin. A diagnosis of primitive neuroectodermal tumor was thus offered. Furthermore, a molecular analysis of our patient using reverse transcription-polymerase chain reaction technique showed positivity for t(11; 22) (q24; q12) (EWSR1-FLI1), thus confirming the diagnosis of a Ewing's sarcoma/primitive neuroectodermal tumor. Our patient was offered chemotherapy on Institutional protocol EFT 2001.
conclusionThis is a rare case of primary vaginal Ewing's sarcoma or primitive neuroectodermal tumor, which was confirmed with molecular analysis, in the youngest patient known so far. This study reinforces the value of integrating morphological features with membranous MIC2 positivity, along with application of molecular techniques in objective identification of an Ewing's sarcoma or primitive neuroectodermal tumor at uncommon sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.