ArticleBMC microbiology2010
Analysis of the genome content of Lactococcus garvieae by genomic interspecies microarray hybridization.
Article in BMC microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Comparative Genomic Analyses of Lactococcus garvieae Isolated from Bovine Mastitis in China.Microbiology spectrum · 2023Article
- Complete genome sequence and description ofNew microbes and new infections · 2016Article
- Lactococcus garvieae: a small bacteria and a big data world.Health information science and systems · 2015Article
- Comparison of alternative mixture model methods to analyze bacterial CGH experiments with multi-genome arrays.BMC research notes · 2014Article
- Comparative transcriptomic analysis of streptococcus pseudopneumoniae with viridans group streptococci.BMC microbiology · 2012Article
- Genome sequence of Lactococcus garvieae 21881, isolated in a case of human septicemia.Journal of bacteriology · 2011Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLactococcus garvieae is a bacterial pathogen that affects different animal species in addition to humans. Despite the widespread distribution and emerging clinical significance of L. garvieae in both veterinary and human medicine, there is almost a complete lack of knowledge about the genetic content of this microorganism. In the present study, the genomic content of L. garvieae CECT 4531 was analysed using bioinformatics tools and microarray-based comparative genomic hybridization (CGH) experiments. Lactococcus lactis subsp. lactis IL1403 and Streptococcus pneumoniae TIGR4 were used as reference microorganisms.
resultsThe combination and integration of in silico analyses and in vitro CGH experiments, performed in comparison with the reference microorganisms, allowed establishment of an inter-species hybridization framework with a detection threshold based on a sequence similarity of >or= 70%. With this threshold value, 267 genes were identified as having an analogue in L. garvieae, most of which (n = 258) have been documented for the first time in this pathogen. Most of the genes are related to ribosomal, sugar metabolism or energy conversion systems. Some of the identified genes, such as als and mycA, could be involved in the pathogenesis of L. garvieae infections.
conclusionsIn this study, we identified 267 genes that were potentially present in L. garvieae CECT 4531. Some of the identified genes could be involved in the pathogenesis of L. garvieae infections. These results provide the first insight into the genome content of L. garvieae.
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