Trial reportPsychophysiology2010
Methylphenidate enhances prepulse inhibition during processing of task-relevant stimuli in attention-deficit/hyperactivity disorder.
Trial report in Psychophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02344784 (The Characteristics of Prepulse Inhibition in Children and Adolescents Suffering From Attention Deficit Disorder), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Characteristics of Prepulse Inhibition in Children and Adolescents Suffering From Attention Deficit Disorder: With and Without Medication.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review.BMC psychology · 2023Pooled it
- Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).The Cochrane database of systematic reviews · 2023Pooled it
- Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).The Cochrane database of systematic reviews · 2015Pooled it
- How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition.Journal of child psychology and psychiatry, and allied disciplines · 2018Trial
- The acoustic startle response in 22q11 deletion syndrome: from animal models to humans.Frontiers in neuroscience · 2025Review
- Sensory Gating in Neurodevelopmental Disorders: A Scoping Review.Research on child and adolescent psychopathology · 2023Article
- Methylphenidate for ADHD in children and adolescents: throwing the baby out with the bathwater.Evidence-based mental health · 2016Article
- Reinforcement and Stimulant Medication Ameliorate Deficient Response Inhibition in Children with Attention-Deficit/Hyperactivity Disorder.Journal of abnormal child psychology · 2016Article
- Comorbidity of ADHD and incontinence in children.European child & adolescent psychiatry · 2015Review
- Article
- Methylphenidate and desipramine combined treatment improves PTSD symptomatology in a rat model.Translational psychiatry · 2014Article
- The effects of performance-based rewards on neurophysiological correlates of stimulus, error, and feedback processing in children with ADHD.Psychophysiology · 2013Article
- Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: initial findings.Psychiatry research · 2013Article
- Effects of smoking abstinence on impulsive behavior among smokers high and low in ADHD-like symptoms.Psychopharmacology · 2012Article
- Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2011Article
- Commentary: enuresis and ADHD in older children and an adolescent treated with stimulant medication: a case series.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2011Article
- Different levels of prepulse inhibition among patients with first-episode schizophrenia, bipolar disorder and major depressive disorder.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
ADHD is characterized by inattention, hyperactivity, and disinhibition, including the inability to screen out distracting stimuli. Prepulse inhibition (PPI) of startle indexes a related gating process and is enhanced during attended compared to ignored stimuli. We predicted that PPI during attended stimuli would be enhanced by the stimulant methylphenidate (MPH) and that this effect would be moderated by baseline PPI. Children with ADHD (n=36) completed a baseline day and a randomized, double-blind medication trial (placebo vs. sustained release MPH). Bilateral startle eyeblink EMG was measured during a tone discrimination task. MPH enhanced PPI during attended, but not during ignored stimuli. Extending findings that pretreatment functioning moderates stimulant effects on PPI, this effect tended to be inversely related to baseline PPI. These data fit with the clinical literature on ADHD and the hypothesis that MPH enhances interference control for important environmental stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.