ArticleOral diseases2010
Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice.
Article in Oral diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Targeted Alkaline Phosphatase Therapy Enhances Alveolar Bone Healing in X-Linked Hypophosphatemia in Mice.Journal of periodontal research · 2026Article
- Article
- Characterization of SIBLING Proteins in the Mineralized Tissues.Dentistry journal · 2022Article
- PHEXGenes · 2022Article
- Effects of Active Vitamin D or FGF23 Antibody onJournal of dental research · 2021Article
- Decompression effects on bone healing in rat mandible osteomyelitis.Scientific reports · 2021Article
- Insights into dental mineralization from three heritable mineralization disorders.Journal of structural biology · 2020Review
- Dentoalveolar Defects in theJournal of dental research · 2020Article
- Disrupted Protein Expression and Altered Proteolytic Events in Hypophosphatemic Dentin Can Be Rescued by Dentin Matrix Protein 1.Frontiers in physiology · 2020Article
- Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis.Scientific reports · 2015Article
- Synthesis of bone-like nanocomposites using multiphosphorylated peptides.Acta biomaterialia · 2014Article
- Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice.PloS one · 2014Article
- The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.The Journal of biological chemistry · 2013Article
- Nuclear localization of DMP1 proteins suggests a role in intracellular signaling.Biochemical and biophysical research communications · 2012Article
- Effect of single-dose amoxicillin on rat incisor odontogenesis: a morphological study.Clinical oral investigations · 2012Article
- Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.Matrix biology : journal of the International Society for Matrix BiologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesHuman X-linked hypophosphatemia (XLH) and its murine homologue, Hyp are caused by inactivating mutations in PHEX gene. The protein encoded by PHEX gene is an endopeptidase whose physiological substrate(s) has not been identified. Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP), two members of the Small Integrin-Binding LIgand, N-linked Glycoprotein (SIBLING) family are proteolytically processed. It has been speculated that PHEX endopeptidase may be responsible for the proteolytic cleavage of DMP1 and DSPP. To test this hypothesis and to analyse the distribution of SIBLING proteins in the predentin/dentin complex and mandible of Hyp mice, we compared the expression of four SIBLING proteins, DMP1, DSPP, bone sialoprotein (BSP) and osteopontin (OPN) between Hyp and wild-type mice.
methodsThese SIBLING proteins were analysed by protein chemistry and immunohistochemistry.
results(1) Dentin matrix protein 1 and DSPP fragments are present in the extracts of Hyp predentin/dentin and bone; (2) the level of DMP1 proteoglycan form, BSP and OPN is elevated in the Hyp bone.
conclusionsThe PHEX protein is not the enzyme responsible for the proteolytic processing of DMP1 and DSPP. The altered distribution of SIBLING proteins may be involved in the pathogenesis of bone and dentin defects in Hyp and XLH.
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Registered trials
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