ArticleInternational journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity2010
Increased oxidative stress and altered substrate metabolism in obese children.
Article in International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024Pooled it
- Soluble receptor for advanced glycation end product (sRAGE) levels in adolescents with obesity, insulin resistance and metabolic syndrome: A case-control study and the review of the literature.BMC endocrine disorders · 2025Observational
- Editorial: Food and immunity: tackling the diseases of the 21st century.Frontiers in nutrition · 2025Article
- Weight loss modifies lipid peroxidation and symmetric dimethylarginine levels in obese dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Consumption of very low-mineral water may threaten cardiovascular health by increasing homocysteine in children.Frontiers in nutrition · 2023Article
- Neutrophil extracellular traps (NETs) modulate inflammatory profile in obese humans and mice: adipose tissue role on NETs levels.Molecular biology reports · 2022Article
- Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status.Frontiers in nutrition · 2022Review
- Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner.Frontiers in nutrition · 2022Article
- Effects of Telephone Follow-Up Intervention on %Body Fat, Inflammatory Cytokines, and Oxidative Stress in Obese Hispanic Children.International journal of environmental research and public health · 2019Article
- Reduced antioxidant capacity and increased subclinical inflammation markers in prepubescent obese children and their relationship with nutritional markers and metabolic parameters.Redox report : communications in free radical research · 2016Article
- Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
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- Obesity is associated with acute inflammation in a sample of adolescents.Pediatric diabetes · 2015Observational
- Oxidative/Antioxidative status in obese and sport trained children: a comparative study.BioMed research international · 2015Article
- A boxing-oriented exercise intervention for obese adolescent males: findings from a pilot study.Journal of sports science & medicine · 2014Article
- Genetics of oxidative stress in obesity.International journal of molecular sciences · 2014Review
- The relationship of oxidative stress, adiposity and metabolic risk factors in healthy Black and White American youth.Pediatric obesity · 2014Article
- Prenatal exposure to nicotine in pregnant rat increased inflammatory marker in newborn rat.Mediators of inflammation · 2014Article
- The Combating Obesity in Māori and Pasifika Adolescent School-Children Study: COMPASS Methodology and Study Protocol.International journal of preventive medicine · 2013Article
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7 authors.
Funding
Abstract
objectivePediatric obesity, a major risk factor for cardiovascular diseases and diabetes, has steadily increased in the last decades. Although excessive inflammation and oxidation are possible biochemical links between obesity and cardiovascular events in adults, little information is available in children. Furthermore, effects of gender and fitness on the interaction between dyslipidemia and oxidative/inflammatory stress in children are mostly unknown.
methodsTherefore, we measured systemic markers of oxidation (F(2)-isoprostanes [F(2)-IsoP] and antioxidants) and inflammation (interleukin-6 [IL-6] and leukocyte counts) and metabolic variables in 113 peripubertal children (55 obese [Ob] age and gender-adjusted BMI% ≥ 95(th), 25 Females [F]; 15 overweight [OW] BMI% 85(th)-95(th), 8 F; 43 normoweight [NW] 25 F).
resultsWhen compared with NW, Ob displayed elevated F(2)-IsoP (99 ± 7 vs. 75 ± 4 pg/mL, p<0.005), IL-6 (2.2 ± 0.2 vs. 1.5 ± 0.3 pg/mL, p<0.005), elevated total leukocytes and neutrophils, altered levels of total cholesterol , low- and high-density-lipoprotein cholesterol, triglycerides, free fatty acids, glucose, and insulin (all p<0.005). This pattern was present in both genders and over a broad range of fitness in Ob.
conclusionsOur data indicate that alterations in metabolic control and a concomitant increase in inflammation and oxidative stress occur early in life in obese children, likely exposing both genders to a similar degree of increased risk of future cardiovascular diseases.
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