ArticleInternational journal of cancer2011
Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes.
Article in International journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Signaling pathways in cancer metabolism: mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Molecular characterization and expression analysis of B-cell lymphoma-2 inFrontiers in immunology · 2023Article
- Conjugated Linoleic Acid Treatment Attenuates Cancerous features in Hepatocellular Carcinoma Cells.Stem cells international · 2022Article
- Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology.Annual review of nutrition · 2016Review
- Lipidome in colorectal cancer.Oncotarget · 2016Review
- Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt.Biochimica et biophysica acta · 2016Article
- In vivo regulation of colonic cell proliferation, differentiation, apoptosis, and P27Kip1 by dietary fish oil and butyrate in rats.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes.Drug metabolism and disposition: the biological fate of chemicals · 2015Article
- SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression.Oncogenesis · 2015Article
- Chemoprotective epigenetic mechanisms in a colorectal cancer model: Modulation by n-3 PUFA in combination with fermentable fiber.Current pharmacology reports · 2015Article
- Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation.Experimental biology and medicine (Maywood, N.J.) · 2014Article
- The microbiome and colorectal neoplasia: environmental modifiers of dysbiosis.Current gastroenterology reports · 2013Review
- Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids.Prostaglandins, leukotrienes, and essential fatty acids · 2013Review
- A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas.Experimental biology and medicine (Maywood, N.J.) · 2012Article
- Article
- Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells.PloS one · 2012Article
- Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARδ in inflammation-induced colon carcinogenesis.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Interactive effects of fatty acid and butyrate-induced mitochondrial Ca²⁺ loading and apoptosis in colonocytes.Cancer · 2011Article
- Classification of diet-modulated gene signatures at the colon cancer initiation and progression stages.Digestive diseases and sciences · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The biological properties of polyunsaturated fatty acid (PUFA) classes have been the source of much contention. For example, n-3 PUFA are chemoprotective, whereas n-6 PUFA may promote tumor development. Since dietary components can have combinatorial effects, we further examined the apoptotic properties of n-3 or n-6 fatty acids when combined with different fiber sources. Mice were fed diets supplemented with either fish oil (FO; enriched in n-3 PUFA) or corn oil (CO; enriched in n-6 PUFA) and nonfermentable (cellulose) or fermentable (pectin) fiber sources. In complementary experiments, immortalized young adult mouse colonic (YAMC) cells were treated with docosahexaenoic acid (DHA; 22:6n-3) or linoleic acid (LA; 18:2n-6) with or without butyrate. Mice fed a FO and pectin diet had significantly (p < 0.05) increased levels of apoptosis in colonocytes compared to all other diets. Similarly, apoptosis was highly induced in DHA and butyrate cotreated YAMC cells. In contrast, in both YAMC and mouse models, LA/CO with butyrate/pectin treatment reduced apoptosis and enhanced expression of bcl-2. The LA and butyrate induced antiapoptotic phenotype was reversed by knocking down bcl-2 using targeted siRNA. In comparison, overexpression of bcl-2 blocked the proapoptotic effect of DHA and butyrate. These data provide new mechanistic insights into the regulation of apoptosis by dietary PUFA and fiber.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.