ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2010
miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans.
Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Decoding Argonaute specificity: insights fromRNA (New York, N.Y.) · 2026Review
- The expanding role of microRNAs in the biology and control of veterinary parasitic nematodes.Frontiers in veterinary science · 2025Review
- Transcriptional and spatiotemporal regulation of the dauer program.Transcription · 2023Review
- A Compilation of the Diverse miRNA Functions inInternational journal of molecular sciences · 2023Review
- Testicular miRNAs and tsRNAs provide insight into gene regulation during overwintering and reproduction of Onychostoma macrolepis.Fish physiology and biochemistry · 2022Article
- A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA.G3 (Bethesda, Md.) · 2021Article
- Variability in β-catenin pulse dynamics in a stochastic cell fate decision in C. elegans.Developmental biology · 2020Article
- TheDevelopment (Cambridge, England) · 2019Article
- The Doubletime HomologG3 (Bethesda, Md.) · 2018Article
- Stage-Specific Timing of the microRNA Regulation of lin-28 by the Heterochronic Gene lin-14 in Caenorhabditis elegans.Genetics · 2017Article
- Article
- The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.PLoS genetics · 2015Article
- Article
- Identification of cis-regulatory modules encoding temporal dynamics during development.BMC genomics · 2014Article
- The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans.Developmental biology · 2014Article
- Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression.PLoS genetics · 2014Article
- DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.Developmental cell · 2014Article
- RILES, a novel method for temporal analysis of the in vivo regulation of miRNA expression.Nucleic acids research · 2013Article
- Functional analysis of neuronal microRNAs in Caenorhabditis elegans dauer formation by combinational genetics and Neuronal miRISC immunoprecipitation.PLoS genetics · 2013Article
- The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition.BMC developmental biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Alteration in the timing of particular developmental events can lead to major morphological changes that have profound effects on the life history of an organism. Insights into developmental timing mechanisms have been revealed in the model organism Caenorhabditis elegans, in which a regulatory network of heterochronic genes times events during larval development, ensuring that stage-specific programs occur in the appropriate sequence and on schedule. Developmental timing studies in C. elegans led to the landmark discovery of miRNAs and continue to enhance our understanding of the regulation and activity of these small regulatory molecules. Current views of the heterochronic gene pathway are summarized here, with a focus on the ways in which miRNAs contribute to temporal control and how miRNAs themselves are regulated. Finally, the conservation of heterochronic genes and their functions in timing, as well as their related roles in stem cells and cancer, are highlighted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.