ArticleClinical orthopaedics and related research2010
Laboratory indicators for early detection and surgical treatment of vibrio necrotizing fasciitis.
Article in Clinical orthopaedics and related research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Necrotising Fasciitis in Patients With Diabetes: A Systematic Review of Mortality-Associated Clinical Factors.International wound journal · 2026Pooled it
- Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2020Pooled it
- Laboratory risk indicator for necrotising fasciitis (LRINEC) score for the assessment of early necrotising fasciitis: a systematic review of the literature.Annals of the Royal College of Surgeons of England · 2017Pooled it
- Correlations between Clinical Features and Mortality in Patients with Vibrio vulnificus Infection.PloS one · 2015Trial
- Early recognition of limb necrotizing fasciitis and surgery within six hours is associated with a lower mortality risk and improved patient-reported outcomes.Bone & joint open · 2026Article
- Diagnostic strategies in necrotizing soft tissue infections: from clinical scores to multi-omics and machine learning.Burns & trauma · 2026Review
- Article
- Initial skin necrosis presentation at emergency room was associated with fulminant clinical course and mortality in patients with Vibrio necrotizing fasciitis.Scientific reports · 2023Article
- Article
- Rational Use of Antibiotics and Education ImprovedAntibiotics (Basel, Switzerland) · 2022Article
- Rational Use of Ceftriaxone in Necrotizing Fasciitis and Mortality Associated with Bloodstream Infection and Hemorrhagic Bullous Lesions.Antibiotics (Basel, Switzerland) · 2022Article
- Article
- Bacteriology and mortality of necrotizing fasciitis in a tertiary coastal hospital with comparing risk indicators of methicillin-resistant Staphylococcus aureus and Vibrio vulnificus infections: a prospective study.BMC infectious diseases · 2021Article
- Different types of bullae of limbs with necrotizing fasciitis predict different outcome: a prospective study.Infection · 2021Article
- International normalised ratio as an independent predictor of mortality in limb necrotising fasciitis with sepsis.Annals of the Royal College of Surgeons of England · 2021Article
- What Demographic and Clinical Factors Are Associated with In-hospital Mortality in Patients with Necrotizing Fasciitis?Clinical orthopaedics and related research · 2020Article
- Predictors for gram-negative monomicrobial necrotizing fasciitis in southern Taiwan.BMC infectious diseases · 2020Article
- Necrotizing fasciitis induced byJournal of orthopaedic translation · 2019Article
- Early clinical manifestations of vibrio necrotising fasciitis.Singapore medical journal · 2018Article
- Risk factors for mortality in the late amputation of necrotizing fasciitis: a retrospective study.World journal of emergency surgery : WJES · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVibrio necrotizing fasciitis is a rare and life-threatening soft tissue infection, with fulminant clinical courses and high mortality rates. However, the lack of specific disease characteristics and diagnostic tools during the initial examination may delay diagnosis. QUESTIONS/PURPOSES: We (1) asked whether the clinical indicators could predict laboratory findings during the initial stage of Vibrio necrotizing fasciitis and (2) determined the relationships between the laboratory risk indicator for necrotizing fasciitis (LRINEC) score and the diagnosis of Vibrio infection.
methodsWe retrospectively reviewed 70 patients with 71 episodes of Vibrio necrotizing fasciitis and sepsis. Of the 70 patients, 68 had a history of contact with seawater or raw seafood; 66 had underlying chronic diseases.
resultsEighteen patients (25.7%) died a mean 18.7 days after admission, and 52 patients survived. A systolic blood pressure of 90 mm Hg or less at the time of admission to the emergency room was associated with mortality. Patients who died had lower leukocyte counts, segmented leukocyte counts, platelet counts, and serum albumin levels compared with the patients who survived and higher counts of band forms of leukocytes. Only eight patients (11%) who survived had a LRINEC score of 6 or greater.
conclusionsThe LRINEC scoring system is not applicable when treating such a highly lethal disease. We propose that severe hypoalbuminemia, severe thrombocytopenia, and increased banded forms of leukocytes are laboratory risk indicators of necrotizing fasciitis that aid in pointing toward initiation of early surgery and predict a higher risk of death. LEVEL OF EVIDENCE: Level III Prognostic study. See the Guidelines for Authors for complete descriptions of levels of evidence.
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