ArticleMycopathologia2010
Molecular analysis of Candida glabrata clinical isolates.
Article in Mycopathologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Phylogenomic analysis and genetic mechanisms of antifungal resistance in clinical isolates ofMicrobiology spectrum · 2026Article
- Review
- Molecular Typing of Candida glabrata.Mycopathologia · 2020Review
- Novel Zinc-Attenuating Compounds as Potent Broad-Spectrum Antifungal Agents withAntimicrobial agents and chemotherapy · 2018Article
- Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity.PloS one · 2018Article
- Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives.Bioorganic & medicinal chemistry letters · 2017Article
- Article
- Evaluation of Polymorphic Locus Sequence Typing for Candida glabrata Epidemiology.Journal of clinical microbiology · 2016Article
- Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species.Memorias do Instituto Oswaldo Cruz · 2016Article
- Overexpression of aldo-keto-reductase in azole-resistant clinical isolates of Candida glabrata determined by cDNA-AFLP.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- Sorbic acid stress activates the Candida glabrata high osmolarity glycerol MAP kinase pathway.Frontiers in microbiology · 2013Article
- Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata.PloS one · 2011Article
- Oxidative stress response and virulence factors in Candida glabrata clinical isolates.Folia microbiologica · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida glabrata is an important human pathogen, and an understanding of the genetic relatedness of its clinical isolates is essential for the prevention and control of fungal infections. In this study, we determined the relatedness of 38 Candida glabrata clinical isolates originating from two teaching hospitals in Slovakia. The 14 different genotypes were found by using microsatellite marker analysis (RPM2, MTI and Cg6) and DNA sequencing for analysis of the entire ERG11 gene. Subsequent sequencing of amplified DNA fragments of the PDR1, NMT1, TRP1 and URA3 loci in ten selected clinical isolates revealed identical DNA sequence profiles in five of them. They displayed the same microsatellite marker sizes and contained the same H576Y amino acid substitution recently described in the Pdr1p multidrug resistance transcription factor responsible for azole resistance. These results demonstrate the genetic diversity of C. glabrata clinical isolates in our hospitals and indicate a common clonal origin of some drug resistant ones.
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