ArticleAnnals of biomedical engineering2010
Carotid atheroma rupture observed in vivo and FSI-predicted stress distribution based on pre-rupture imaging.
Article in Annals of biomedical engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Biomechanical assessment of vulnerable plaque: from histological evidence to ultrasound elastography and image-based computational patient-specific modelling.Frontiers in bioengineering and biotechnology · 2025Article
- Time-dependent simulation of blood flow through an abdominal aorta with iliac arteries.European biophysics journal : EBJ · 2024Article
- Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters.Heliyon · 2024Article
- 3D patient-specific modeling and structural finite element analysis of atherosclerotic carotid artery based on computed tomography angiography.Scientific reports · 2023Article
- Plaque Structural Stress: Detection, Determinants and Role in Atherosclerotic Plaque Rupture and Progression.Frontiers in cardiovascular medicine · 2022Review
- Accurate Calculation of FFR Based on a Physics-Driven Fluid-Structure Interaction Model.Frontiers in physiology · 2022Article
- Identification of intra-individual variation in intracranial arterial flow by MRI and the effect on computed hemodynamic descriptors.Magma (New York, N.Y.) · 2021Article
- The Association Between Time-Varying Wall Shear Stress and the Development of Plaque Ulcerations in Carotid Arteries From the Plaque at Risk Study.Frontiers in cardiovascular medicine · 2021Article
- Combining morphological and biomechanical factors for optimal carotid plaque progression prediction: An MRI-based follow-up study using 3D thin-layer models.International journal of cardiology · 2019Article
- Progressive changes of elastic moduli of arterial wall and atherosclerotic plaque components during plaque development in human coronary arteries.Medical & biological engineering & computing · 2019Article
- Stress analysis of fracture of atherosclerotic plaques: crack propagation modeling.Medical & biological engineering & computing · 2017Article
- PI16 is a shear stress and inflammation-regulated inhibitor of MMP2.Scientific reports · 2016Article
- 3D MRI-based multicomponent thin layer structure only plaque models for atherosclerotic plaques.Journal of biomechanics · 2016Article
- The influence of constitutive law choice used to characterise atherosclerotic tissue material properties on computing stress values in human carotid plaques.Journal of biomechanics · 2015Article
- The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses.Journal of biomechanics · 2014Article
- Plaque hemorrhage in carotid artery disease: pathogenesis, clinical and biomechanical considerations.Journal of biomechanics · 2014Review
- Changing views of the biomechanics of vulnerable plaque rupture: a review.Annals of biomedical engineering · 2014Review
- Higher critical plaque wall stress in patients who died of coronary artery disease compared with those who died of other causes: a 3D FSI study based on ex vivo MRI of coronary plaques.Journal of biomechanics · 2014Article
- Article
- High wall shear stress and spatial gradients in vascular pathology: a review.Annals of biomedical engineering · 2013Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Atherosclerosis at the carotid bifurcation is a major risk factor for stroke. As mechanical forces may impact lesion stability, finite element studies have been conducted on models of diseased vessels to elucidate the effects of lesion characteristics on the stresses within plaque materials. It is hoped that patient-specific biomechanical analyses may serve clinically to assess the rupture potential for any particular lesion, allowing better stratification of patients into the most appropriate treatments. Due to a sparsity of in vivo plaque rupture data, the relationship between various mechanical descriptors such as stresses or strains and rupture vulnerability is incompletely known, and the patient-specific utility of biomechanical analyses is unclear. In this article, we present a comparison between carotid atheroma rupture observed in vivo and the plaque stress distribution from fluid-structure interaction analysis based on pre-rupture medical imaging. The effects of image resolution are explored and the calculated stress fields are shown to vary by as much as 50% with sub-pixel geometric uncertainty. Within these bounds, we find a region of pronounced elevation in stress within the fibrous plaque layer of the lesion with a location and extent corresponding to that of the observed site of plaque rupture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.