ArticleCellular and molecular neurobiology2010
Neuronal MHC class I molecules are involved in excitatory synaptic transmission at the hippocampal mossy fiber synapses of marmoset monkeys.
Article in Cellular and molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- The neuroimmune system and cognition.Nature immunology · 2026Review
- Adult human neurogenesis: A view from two schools of thought.IBRO neuroscience reports · 2023Review
- Neuronal MHC-I complex is destabilized by amyloid-β and its implications in Alzheimer's disease.Cell & bioscience · 2023Article
- Tight Regulation of Major Histocompatibility Complex I for the Spatial and Temporal Expression in the Hippocampal Neurons.Frontiers in cellular neuroscience · 2021Review
- The functional microscopic neuroanatomy of the human subthalamic nucleus.Brain structure & function · 2019Article
- Immunoglobulin-Like Receptors and Their Impact on Wiring of Brain Synapses.Annual review of genetics · 2018Review
- Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons.Annals of clinical and translational neurology · 2018Article
- PirB regulates asymmetries in hippocampal circuitry.PloS one · 2017Article
- Developmental expression and localization of MHC class I molecules in the human central nervous system.Experimental brain research · 2015Article
- Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain.Neurochemical research · 2015Article
- Chronic desipramine prevents acute stress-induced reorganization of medial prefrontal cortex architecture by blocking glutamate vesicle accumulation and excitatory synapse increase.The international journal of neuropsychopharmacology · 2014Article
- Major histocompatibility complex I in brain development and schizophrenia.Biological psychiatry · 2014Review
- The similar expression pattern of MHC class I molecules in human and mouse cerebellar cortex.Neurochemical research · 2014Article
- Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry.The Journal of physiology · 2013Article
- The expression pattern of classical MHC class I molecules in the development of mouse central nervous system.Neurochemical research · 2013Article
- The major histocompatibility complex and autism spectrum disorder.Developmental neurobiology · 2012Review
- Dynamic gene expression in the human cerebral cortex distinguishes children from adults.PloS one · 2012Article
- Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey.Behavioral and brain functions : BBF · 2011Article
- MHC class I molecules are present both pre- and postsynaptically in the visual cortex during postnatal development and in adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders.Frontiers in synaptic neuroscience · 2010Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent studies suggested a role for neuronal major histocompatibility complex class I (MHCI) molecules in certain forms of synaptic plasticity in the hippocampus of rodents. Here, we report for the first time on the expression pattern and functional properties of MHCI molecules in the hippocampus of a nonhuman primate, the common marmoset monkey (Callithrix jacchus). We detected a presynaptic, mossy fiber-specific localization of MHCI proteins within the marmoset hippocampus. MHCI molecules were present in the large, VGlut1-positive, mossy fiber terminals, which provide input to CA3 pyramidal neurons. Furthermore, whole-cell recordings of CA3 pyramidal neurons in acute hippocampal slices of the common marmoset demonstrated that application of antibodies which specifically block MHCI proteins caused a significant decrease in the frequency, and a transient increase in the amplitude, of spontaneous excitatory postsynaptic currents (sEPSCs) in CA3 pyramidal neurons. These findings add to previous studies on neuronal MHCI molecules by describing their expression and localization in the primate hippocampus and by implicating them in plasticity-related processes at the mossy fiber-CA3 synapses. In addition, our results suggest significant interspecies differences in the localization of neuronal MHCI molecules in the hippocampus of mice and marmosets, as well as in their potential function in these species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.