ArticleMedical microbiology and immunology2010
The CFP-10/ESAT-6 complex of Mycobacterium tuberculosis potentiates the activation of murine macrophages involvement of IFN-gamma signaling.
Article in Medical microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2.Respiratory research · 2025Article
- Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses.Medical microbiology and immunology · 2016Article
- Association of genetic variants in Wnt signaling pathway with tuberculosis in Chinese Han population.PloS one · 2014Article
- Serodiagnosis efficacy and immunogenicity of the fusion protein of Mycobacterium tuberculosis composed of the 10-kilodalton culture filtrate protein, ESAT-6, and the extracellular domain fragment of PPE68.Clinical and vaccine immunology : CVI · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secretory antigen of Mycobacterium tuberculosis, culture filtered protein 10(CFP-10) and early secreted antigenic target 6 kDa protein (ESAT-6) are closely correlated with immunogenicity and virulence of Mycobacterium tuberculosis. But the mechanism of its immunogenicity and virulence is still unclear. In this study, we investigated the influence of the CFP-10/ESAT-6 complex on production of IL-12 and nitric oxide (NO) produced by the ANA-1 macrophage cell line. Preincubation with the complex in a time-dependent manner significantly enhanced production of NO and IL-12 released from ANA-1 cells following IFN-gamma stimulation. In addition, the complex up-modulated expression level of IFN-gammaR1 on surface of the macrophages. Furthermore, the effect of the complex on production of IL-12 and NO in ANA-1 cells was suppressed by AG490, a selective inhibitor of JAK/STAT pathway. These data suggest that in the presence of IFN-gamma, CFP-10/ESAT-6 complex represents a new immunogenicity and protective factor that may be, at least partly, due to up modulation of IFN-gammaR1 expression and activation of JAK/STAT pathway.
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