ArticlePloS one2010
Increased iron stores correlate with worse disease outcomes in a mouse model of schistosomiasis infection.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Hepatic iron accumulation is reduced in the cholestatic Mdr2-/- mouse.Bioscience reports · 2026Article
- Clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis induced by Leishmania infantum infection.PLoS neglected tropical diseases · 2021Article
- The effect of the flavonol rutin on serum and liver iron content in a genetic mouse model of iron overload.Bioscience reports · 2021Article
- Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.Bioscience reports · 2020Article
- Molecular characterization of transport lectin vesicular integral membrane protein 36 kDa (VIP36) in the life cycle of Schistosoma mansoni.Parasitology research · 2017Article
- Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection.BMC infectious diseases · 2017Article
- Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections.Current opinion in microbiology · 2015Review
- Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin.Scientific reports · 2015Article
- Hepcidin: regulation of the master iron regulator.Bioscience reports · 2015Review
- Biochemical characterization and role of the proteasome in the oxidative stress response of adult Schistosoma mansoni worms.Parasitology research · 2014Article
- Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries.Pathogens and global health · 2012Review
- Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium.Journal of parasitology research · 2012Article
- Nifedipine affects the course of Salmonella enterica serovar Typhimurium infection by modulating macrophage iron homeostasis.The Journal of infectious diseases · 2011Article
- Iron and the immune system.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Schistosoma mansoni soluble egg antigens trigger erythrocyte cell death.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis is a significant parasitic infection creating disease burden throughout many of the world's developing nations. Iron deficiency anemia is also a significant health burden resulting from both nutritional deficit as well as parasitic infection in these countries. In this study we investigated the relationships between the disease outcomes of Schistosoma japonicum infection and iron homeostasis. We aimed to determine if host iron status has an effect on schistosome maturation or egg production, and to investigate the response of iron regulatory genes to chronic schistosomiasis infection. Wild-type C57BL/6 and Transferrin Receptor 2 null mice were infected with S. japonicum, and sacrificed at the onset of chronic disease. Transferrin Receptor 2 null mice are a model of type 3 hereditary hemochromatosis and develop significant iron overload providing increased iron stores at the onset of infection. The infectivity of schistosomes and egg production was assessed along with the subsequent development of granulomas and fibrosis. The response of the iron regulatory gene Hepcidin to infection and the changes in iron status were assessed by real-time PCR and Western blotting. Our results show that Hepcidin levels responded to the changing iron status of the animals, but were not significantly influenced by the inflammatory response. We also show that with increased iron availability at the time of infection there was greater development of fibrosis around granulomas. In conclusion, our studies indicate that chronic inflammation may not be the primary cause of the anemia seen in schistosomiasis, and suggest that increased availability of iron, such as through iron supplementation, may actually lead to increased disease severity.
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