ArticleNature biotechnology2010
V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets.
Article in Nature biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 357 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
357 citing papers in PubMed.
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
- Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons.Cell reports · 2026Article
- Article
- Multimodal characterization of variation in neuronal types in the mouse basal ganglia.bioRxiv : the preprint server for biology · 2026Article
- A quantitative and precision‑oriented neuronal reconstruction approach based on data grading.Brain informatics · 2026Article
- MASCAF: A Cable Model Fitting Pipeline for Topologically Complex Surface Meshes.bioRxiv : the preprint server for biology · 2026Article
- Article
- Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.bioRxiv : the preprint server for biology · 2026Article
- BVLab-analyzer: a unified visual toolbox for terabyte-scale whole-brain cell detection, neuron reconstruction, and vascular network extraction.Frontiers in neuroinformatics · 2026Article
- Confocal Airy beam oblique light-sheet tomography for brain-wide cell type distribution and morphology.Nature methods · 2025Article
- Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.Biophysical journal · 2025Review
- A deep learning pipeline for accurate and automated restoration, segmentation, and quantification of dendritic spines.Cell reports methods · 2025Article
- Distinct subnetworks of the mouse anterior thalamic nuclei.Nature communications · 2025Article
- Filopodia are essential for steroid release.Nature communications · 2025Article
- Article
- A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images.Scientific data · 2025Article
- Twenty Years of Neuroinformatics: A Bibliometric Analysis.Neuroinformatics · 2025Review
- Super-resolution microscopy and deep learning methods: what can they bring to neuroscience: from neuron to 3D spine segmentation.Frontiers in neuroinformatics · 2025Review
- Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.Human molecular genetics · 2024Article
- Visualizing Volumetric and Segmentation Data using Mol* Volumes & Segmentations 2.0.Current protocols · 2024Article
297 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
The V3D system provides three-dimensional (3D) visualization of gigabyte-sized microscopy image stacks in real time on current laptops and desktops. V3D streamlines the online analysis, measurement and proofreading of complicated image patterns by combining ergonomic functions for selecting a location in an image directly in 3D space and for displaying biological measurements, such as from fluorescent probes, using the overlaid surface objects. V3D runs on all major computer platforms and can be enhanced by software plug-ins to address specific biological problems. To demonstrate this extensibility, we built a V3D-based application, V3D-Neuron, to reconstruct complex 3D neuronal structures from high-resolution brain images. V3D-Neuron can precisely digitize the morphology of a single neuron in a fruitfly brain in minutes, with about a 17-fold improvement in reliability and tenfold savings in time compared with other neuron reconstruction tools. Using V3D-Neuron, we demonstrate the feasibility of building a 3D digital atlas of neurite tracts in the fruitfly brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.