ArticleArchives of surgery (Chicago, Ill. : 1960)2010
Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells.
Article in Archives of surgery (Chicago, Ill. : 1960), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Determination of Burn Size in Mouse Models of Burn Injury: A Scoping Review of Studies Leveraging Scald and Contact Burns.Journal of burn care & research : official publication of the American Burn Association · 2025Pooled it
- The Oxylipin Dependent Quorum Sensing System enhances Pseudomonas aeruginosa dissemination during burn-associated infection.PLoS pathogens · 2026Article
- Amino Acid-Based Protein-Mimic Hydrogel Incorporating Pro-Regenerative Lipid Mediator and Microvascular Fragments Promotes the Healing of Deep Burn Wounds.International journal of molecular sciences · 2024Article
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- Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds.Burns & trauma · 2021Article
- Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation.Annals of surgery · 2019Article
- Non-Propellant Foams of Green Nano-Silver and Sulfadiazine: Development and In Vivo Evaluation for Burn Wounds.Pharmaceutical research · 2019Article
- The Cutaneous Inflammatory Response to Thermal Burn Injury in a Murine Model.International journal of molecular sciences · 2019Article
- Combination of the stromal vascular fraction and platelet-rich plasma accelerates the wound healing process: pre-clinical study in a Sprague-Dawley rat model.Stem cell investigation · 2019Article
- Accelerate Healing of Severe Burn Wounds by Mouse Bone Marrow Mesenchymal Stem Cell-Seeded Biodegradable Hydrogel Scaffold Synthesized from Arginine-Based Poly(ester amide) and Chitosan.Stem cells and development · 2018Article
- Topical Reformulation of Valsartan for Treatment of Chronic Diabetic Wounds.The Journal of investigative dermatology · 2018Article
- Endothelial progenitor cells and burn injury - exploring the relationship.Burns & trauma · 2016Review
- Article
- Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model.The Journal of investigative dermatology · 2015Article
- Full-Thickness Thermal Injury Delays Wound Closure in a Murine Model.Advances in wound care · 2015Article
- Combination of HIF-1α gene transfection and HIF-1-activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice.Gene therapy · 2013Article
- Integration and regression of implanted engineered human vascular networks during deep wound healing.Stem cells translational medicine · 2013Article
- Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells.Cardiovascular research · 2012Article
- Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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Authors and funding
12 authors at 1 institution in 4 countries.
Funding
Abstract
objectiveTo perform a systematic exploration of the phenomenon of mobilization of circulating angiogenic cells (CACs) in an animal model. This phenomenon has been observed in patients with cutaneous burn wounds and may be an important mechanism for vasculogenesis in burn wound healing.
designWe used a murine model, in which burn depth can be varied precisely, and a validated culture method for quantifying circulating CACs.
settingMichael D. Hendrix Burn Research Center, Baltimore, Maryland.
participantsMale 129S1/SvImJ mice, aged 8 weeks, and 31 patients aged 19-59 years with burn injury on 1% to 64% of the body surface area and evidence of hemodynamic stability.
main outcome measuresBurn wound histological features, including immunohistochemistry for blood vessels with CD31 and alpha-smooth muscle actin antibodies, blood flow measured with laser Doppler perfusion imaging, and mobilization of CACs into circulating blood measured with a validated culture technique.
resultsIncreasing burn depth resulted in a progressive delay in the time to mobilization of circulating CACs and reduced mobilization of CACs. This delay and reduction in CAC mobilization was associated with reduced perfusion and vascularization of the burn wound tissue. Analysis of CACs in the peripheral blood of the human patients, using a similar culture assay, confirmed results previously obtained by flow cytometry, that CAC levels peak early after the burn wound.
conclusionIf CAC mobilization and wound perfusion are important determinants of clinical outcome, then strategies designed to augment angiogenic responses may improve outcome in patients with severe burn wounds.
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