ArticleThe Journal of general physiology2010
Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.
Article in The Journal of general physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- cAMP-Mediated Modulation of Functions of Green- and Blue-Sensitive Cones in Zebrafish.International journal of molecular sciences · 2025Article
- Article
- Biochemistry and physiology of zebrafish photoreceptors.Pflugers Archiv : European journal of physiology · 2021Review
- Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics.Frontiers in cellular neuroscience · 2021Review
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- Temporal information loss in the macaque early visual system.PLoS biology · 2020Article
- Multi-scale, numerical modeling of spatio-temporal signaling in cone phototransduction.PloS one · 2019Article
- Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors.Progress in retinal and eye research · 2018Review
- The Binding Properties and Physiological Functions of Recoverin.Frontiers in molecular neuroscience · 2018Review
- Recoverin depletion accelerates cone photoresponse recovery.Open biology · 2015Article
- Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.The Journal of biological chemistry · 2015Article
- Activation and quenching of the phototransduction cascade in retinal cones as inferred from electrophysiology and mathematical modeling.Molecular vision · 2015Article
- Timing is everything: GTPase regulation in phototransduction.Investigative ophthalmology & visual science · 2013Review
- Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models.Progress in retinal and eye research · 2012Review
- Origin and control of the dominant time constant of salamander cone photoreceptors.The Journal of general physiology · 2012Article
- Photoreceptor signaling: supporting vision across a wide range of light intensities.The Journal of biological chemistry · 2012Review
- Speed, adaptation, and stability of the response to light in cone photoreceptors: the functional role of Ca-dependent modulation of ligand sensitivity in cGMP-gated ion channels.The Journal of general physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The time scale of the photoresponse in photoreceptor cells is set by the slowest of the steps that quench the light-induced activity of the phototransduction cascade. In vertebrate photoreceptor cells, this rate-limiting reaction is thought to be either shutoff of catalytic activity in the photopigment or shutoff of the pigment's effector, the transducin-GTP-phosphodiesterase complex. In suction pipette recordings from isolated salamander L-cones, we found that preventing changes in internal [Ca(2+)] delayed the recovery of the light response and prolonged the dominant time constant for recovery. Evidence that the Ca(2+)-sensitive step involved the pigment itself was provided by the observation that removal of Cl(-) from the pigment's anion-binding site accelerated the dominant time constant for response recovery. Collectively, these observations indicate that in L-cones, unlike amphibian rods where the dominant time constant is insensitive to [Ca(2+)], pigment quenching rate limits recovery and provides an additional mechanism for modulating the cone response during light adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.