ArticleMolecular and cellular biology2010
Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Role of Autotaxin in High Glucose-Induced Human ARPE-19 Cells.International journal of molecular sciences · 2022Article
- NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment.Cellular and molecular life sciences : CMLS · 2021Article
- Lysolipids in Vascular Development, Biology, and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration?International journal of molecular sciences · 2020Review
- Pleotropic Roles of Autotaxin in the Nervous System Present Opportunities for the Development of Novel Therapeutics for Neurological Diseases.Molecular neurobiology · 2020Review
- Review
- Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression.Journal of lipid research · 2016Review
- Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels.The Journal of biological chemistry · 2015Article
- Article
- Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2014Review
- Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.The Journal of biological chemistry · 2013Article
- Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy.Diabetologia · 2013Article
- Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA).Bioscience reports · 2012Article
- MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy.The American journal of pathology · 2012Article
- Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid.Diabetes · 2012Article
- Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells.Atherosclerosis · 2012Article
- Axl is essential for VEGF-A-dependent activation of PI3K/Akt.The EMBO journal · 2012Article
- Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro.Journal of experimental & clinical cancer research : CR · 2012Article
- Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.Biochemical Society transactions · 2012Review
- Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis.Molecular cancer · 2011Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
We previously reported that vascular endothelial growth factor (VEGF)-dependent activation of phospholipase Cgamma1 (PLCgamma) regulated tube stability by competing with phosphoinositide 3-kinase (PI3K) for their common substrate. Here we describe an additional mechanism by which PLCgamma promoted regression of tubes and blood vessels. Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospholipase D that produces lysophosphatidic acid (LPA). LPA promoted motility of endothelial cells, leading to disorganization/regression of tubes in vitro. Furthermore, mice that under- or overexpressed members of this intrinsic destabilization pathway showed either delayed or accelerated, respectively, regression of blood vessels. We conclude that endothelial cells can be instructed to engage a PLCgamma-dependent intrinsic destabilization pathway that results in the production of soluble regression factors such as ATX and LPA. These findings are likely to potentiate ongoing efforts to prevent, manage, and eradicate numerous angiogenesis-based diseases such as proliferative diabetic retinopathy and solid tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.