Evidence map›Paper›PMID 20231323›Full record

ReviewThe American journal of psychiatry2010

Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits.

Avshalom Caspi, Ahmad R Hariri, Andrew Holmes, Rudolf Uher, Terrie E Moffitt

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03795688 (The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health), which is not on this map. Cited by 533 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
533citing papers in PubMed, 14 pooled it
52.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03795688 completednot on this mapstarted 2019, after this paper: background citation

The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health

Typeobservational_patient_registrySponsorVibe G Frøkjær, MD, PhDRan2019 to 2020Enrolled100ConditionsMajor Depressive Disorder, Perinatal DepressionArmsPregnancy
3 · Its place in the literature

Who cites it

533 citing papers in PubMed, 14 syntheses or guidelines pooled it, 1,345 citations in OpenAlex.

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  9. Imaging genetics paradigms in depression research: Systematic review and meta-analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2018
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473 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Avshalom CaspiDepartment of Psychology, and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA. ac115@duke.edu
Ahmad R Hariri
Andrew Holmes
Rudolf Uher
Terrie E Moffitt
Duke University · US

Funding

Mouse models of stress disorders and addictionZIAAA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2009 to 2025
$37.7M
Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Uncovering and confirming gene-environment interactions in psychopathologyR01MH077874 · NIMH · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2007 to 2010
$1.6M
Development of Amygdala-Prefrontal InteractionsK01MH072837 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARIRI, AHMAD R. · 2005 to 2009
$798k
Social Inequality and Children's Mental HealthR01HD061298 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2009 to 2012
$478k
Intramural NIH HHS ZIA AA000411Medical Research Council G0100527Medical Research Council G0601483Medical Research Council G9806489NIA NIH HHS AG032282NIA NIH HHS R01 AG032282NICHD NIH HHS HD061298NICHD NIH HHS R01 HD061298NIMH NIH HHS K01 MH072837NIMH NIH HHS MH072837NIMH NIH HHS MH077874NIMH NIH HHS R01 MH077874
6 · The paper itself

Abstract

Evidence of marked variability in response among people exposed to the same environmental risk implies that individual differences in genetic susceptibility might be at work. The study of such Gene-by-Environment (GxE) interactions has gained momentum. In this article, the authors review research about one of the most extensive areas of inquiry: variation in the promoter region of the serotonin transporter gene (SLC6A4; also known as 5-HTT) and its contribution to stress sensitivity. Research in this area has both advanced basic science and generated broader lessons for studying complex diseases and traits. The authors evaluate four lines of evidence about the 5-HTT stress-sensitivity hypothesis: 1) observational studies about the serotonin transporter linked polymorphic region (5-HTTLPR), stress sensitivity, and depression in humans; 2) experimental neuroscience studies about the 5-HTTLPR and biological phenotypes relevant to the human stress response; 3) studies of 5-HTT variation and stress sensitivity in nonhuman primates; and 4) studies of stress sensitivity and genetically engineered 5-HTT mutations in rodents. The authors then dispel some misconceptions and offer recommendations for GxE research. The authors discuss how GxE interaction hypotheses can be tested with large and small samples, how GxE research can be carried out before as well as after replicated gene discovery, the uses of GxE research as a tool for gene discovery, the importance of construct validation in evaluating GxE research, and the contribution of GxE research to the public understanding of genetic science.

Indexed as

AnimalsBrainDepressive DisorderEnvironmentGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansModels, PsychologicalMood DisordersPrimatesSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID20231323
PMCPMC2943341
OpenAlexW2100230238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.