ArticleThe Journal of biological chemistry2010
Dual roles of smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 77 citations in OpenAlex.
- Pharmacological PIK3C2B inhibition rescues XLMTM phenotype in mouse models and identifies molecular markers of disease.JCI insight · 2026Article
- ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation.EMBO reports · 2024Article
- Sex hormone-binding globulin promotes the osteogenic differentiation potential of equine adipose-derived stromal cells by activating the BMP signaling pathway.Frontiers in endocrinology · 2024Article
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- Article
- Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells.Cells · 2022Review
- Article
- Article
- Bu-M-P-ing Iron: How BMP Signaling Regulates Muscle Growth and Regeneration.Journal of developmental biology · 2020Review
- Article
- Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by RegulatingAntioxidants (Basel, Switzerland) · 2019Article
- 5'-hydroxy Auraptene stimulates osteoblast differentiation of bone marrow-derived mesenchymal stem cells via a BMP-dependent mechanism.Journal of biomedical science · 2019Article
- Discovery of Heterotopic Bone-Inducing Activity in Hard Tissues and the TGF-β Superfamily.International journal of molecular sciences · 2018Review
- Recent Topics in Fibrodysplasia Ossificans Progressiva.Endocrinology and metabolism (Seoul, Korea) · 2018Review
- Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation.Scientific reports · 2018Article
- Icariin: a Potential Compound for the Recovery of Tibial Dyschondroplasia Affected Chicken Via Up-Regulating BMP-2 Expression.Biological procedures online · 2018Article
- Distinct cis-acting regions control six6 expression during eye field and optic cup stages of eye formation.Developmental biology · 2017Article
- Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2.Nature communications · 2016Article
- E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Bone Morphogenetic Proteins.Cold Spring Harbor perspectives in biology · 2016Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenetic proteins (BMPs) induce ectopic bone formation in muscle tissue in vivo and convert myoblasts such that they differentiate into osteoblastic cells in vitro. We report here that constitutively active Smad1 induced osteoblastic differentiation of C2C12 myoblasts in cooperation with Smad4 or Runx2. In floxed Smad4 mice-derived cells, Smad4 ablation partially suppressed BMP-4-induced osteoblast differentiation. In contrast, the BMP-4-induced inhibition of myogenesis was lost by Smad4 ablation and restored by Smad4 overexpression. A nuclear zinc finger protein, E4F1, was identified as a possible component of the Smad4 complex that suppresses myogenic differentiation in response to BMP signaling. In the presence of Smad4, E4F1 stimulated the expression of Ids. Taken together, these findings suggest that the Smad signaling pathway may play a dual role in the BMP-induced conversion of myoblasts to osteoblastic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.