ArticlePediatrics2010
Catheter duration and risk of CLA-BSI in neonates with PICCs.
Article in Pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03730883 (The Effect of Early Versus Standard Central Line Removal on Growth of Very Low Birth Weight Premature Infants), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Early Versus Standard Central Line Removal on Growth of Very Low Birth Weight Premature Infants: A Non-inferiority, Randomized Controlled Trial
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Antimicrobial dressings for the prevention of catheter-related infections in newborn infants with central venous catheters.The Cochrane database of systematic reviews · 2016Pooled it
- Antibiotic lock for the prevention of catheter-related infection in neonates.The Cochrane database of systematic reviews · 2015Pooled it
- Does ultrasound guidance for peripherally inserted central catheter (PICC) insertion reduce the incidence of tip malposition? - a randomized trial.Journal of perinatology : official journal of the California Perinatal Association · 2019Trial
- Catheter Duration Threshold and Risk Factors for Central Line-Associated Bloodstream Infections in a Tertiary ICU with Endemic Carbapenem Resistance: A Case-Control Study.Antibiotics (Basel, Switzerland) · 2026Article
- Umbilical and Peripheral Venous Catheter-Related Outcomes in Premature Neonates.Children (Basel, Switzerland) · 2025Article
- The impact of central line-specific dwell-times for neonatal central line associated bloodstream infections.Antimicrobial resistance and infection control · 2025Article
- Differences in the Dwell Time of Peripherally Inserted Central Catheters between Patients with Catheter Colonization and Those Developing Central Line-Associated Bloodstream Infection: A Single Centre Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2024Article
- Ultrasound-Guided Centrally Inserted Central Catheter (CICC) Placement in Newborns: A Safe Clinical Training Program in a Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2024Article
- The neonatal DAV-expert algorithm: a GAVeCeLT/GAVePed consensus for the choice of the most appropriate venous access in newborns.European journal of pediatrics · 2023Article
- Clinical factors associated with peripherally inserted central catheters (PICC) related bloodstream infections: a single centre retrospective cohort.Antimicrobial resistance and infection control · 2023Article
- Central Venous Catheter-Related Infectious Complications in Pediatric Surgical Patients: A Single-Center Experience.Journal of pediatric intensive care · 2022Article
- Duration of central venous catheter placement and central line-associated bloodstream infections after the adoption of prevention bundles: a two-year retrospective study.Antimicrobial resistance and infection control · 2022Article
- Risk factors for central venous catheter-associated deep venous thrombosis in pediatric critical care settings identified by fusion model.Thrombosis journal · 2022Article
- Peripherally inserted central catheters have a protective role and the effect of fluctuation curve feature in the risk of bloodstream infection compared with central venous catheters: a propensity-adjusted analysis.BMC infectious diseases · 2022Article
- Unilateral nephrectomy for young infants with congenital nephrotic syndrome of the Finnish type.Clinical and experimental nephrology · 2022Article
- The Effect of a Single Dose of Prophylactic Vancomycin Prior to Peripherally Inserted Central Catheter Removal on Sepsis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants.Scientific reports · 2021Article
- Line days as a determinant of central line-associated bloodstream infections in pediatric patients with tunneled femoral peripherally inserted central catheters.Pediatric radiology · 2021Article
- Infection Prevention in the Neonatal Intensive Care Unit.Clinics in perinatology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether the risk of central line-associated bloodstream infections (CLA-BSIs) remained constant over the duration of peripherally inserted central venous catheters (PICCs) in high-risk neonates. PATIENT AND
methodsWe performed a retrospective cohort study of NICU patients who had a PICC inserted between January 1, 2006, and December 31, 2008. A Poisson regression model with linear spline terms to model time since PICC insertion was used to evaluate potential changes in the risk of CLA-BSI while adjusting for other variables.
resultsSix hundred eighty-three neonates were eligible for analysis. There were 21 CLA-BSIs within a follow-up period of 10 470 catheter-days. The incidence of PICC-associated CLA-BSI was 2.01 per 1 000 catheter-days (95% confidence interval [CI]: 1.24-3.06). The incidence rate of CLA-BSIs increased by 14% per day during the first 18 days after PICC insertion (incidence rate ratio [IRR]: 1.14 [95% CI: 1.04-1.25]). From days 19 through 35 after PICC insertion, the trend reversed (IRR: 0.8 [95% CI: 0.66-0.96]). From days 36 through 60 after PICC insertion, the incidence rate of CLA-BSI again increased by 33% per day (IRR: 1.33 [95% CI: 1.12-1.57]). There was no statistically significant association between the risk of CLA-BSI and gestational age groups, birth weight groups, or chronological age groups.
conclusionsOur data suggest that catheter duration is an important risk factor for PICC-associated CLA-BSI in the NICU. A significant daily increase in the risk of CLA-BSI after 35 days may warrant PICC replacement if intravascular access is necessary beyond that period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.