ArticleActa biomaterialia2010
Microwave-processed nanocrystalline hydroxyapatite: simultaneous enhancement of mechanical and biological properties.
Article in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cold-sintered bioceramics for medical applications: State of the art and further perspectives.Biomaterials translational · 2025Review
- Impact of Particle Size and Sintering Temperature on Calcium Phosphate Gyroid Structure Scaffolds for Bone Tissue Engineering.Journal of functional biomaterials · 2024Article
- Review
- Applying extrusion-based 3D printing technique accelerates fabricating complex biphasic calcium phosphate-based scaffolds for bone tissue regeneration.Journal of advanced research · 2022Review
- Microwave Treatment of Calcium Phosphate/Titanium Dioxide Composite to Improve Protein Adsorption.Materials (Basel, Switzerland) · 2022Article
- Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size.Bioactive materials · 2022Article
- Synthesis, Characterization, Functionalization and Bio-Applications of Hydroxyapatite Nanomaterials: An Overview.International journal of nanomedicine · 2022Review
- Mechanical, Electrical, and Biological Properties of Mechanochemically Processed Hydroxyapatite Ceramics.Nanomaterials (Basel, Switzerland) · 2021Article
- Article
- Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure.Journal of biomedical materials research. Part A · 2018Article
- A novel two-step sintering for nano-hydroxyapatite scaffolds for bone tissue engineering.Scientific reports · 2014Article
- Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.PloS one · 2014Article
- Microwave-sintered 3D printed tricalcium phosphate scaffolds for bone tissue engineering.Journal of tissue engineering and regenerative medicine · 2013Article
- Nanocrystalline spherical hydroxyapatite granules for bone repair: in vitro evaluation with osteoblast-like cells and osteoclasts.Journal of materials science. Materials in medicine · 2013Article
- Understanding in vivo response and mechanical property variation in MgO, SrO and SiO₂ doped β-TCP.Bone · 2011Article
- Electrically polarized biphasic calcium phosphates: adsorption and release of bovine serum albumin.Langmuir : the ACS journal of surfaces and colloids · 2010Article
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Authors and funding
4 authors.
Funding
Abstract
Despite the excellent bioactivity of hydroxyapatite (HA) ceramics, poor mechanical strength has limited the applications of these materials primarily to coatings and other non-load-bearing areas as bone grafts. Using synthesized HA nanopowder, dense compacts with grain sizes in the nanometer to micrometer range were processed via microwave sintering between 1000 and 1150 degrees C for 20 min. Here we demonstrate that the mechanical properties, such as compressive strength, hardness and indentation fracture toughness, of HA compacts increased with a decrease in grain size. HA with 168 +/- 86 nm grain size showed the highest compressive strength of 395 +/- 42 MPa, hardness of 8.4+/-0.4 GPa and indentation fracture toughness of 1.9 +/- 0.2 MPa m(1/2). To study the in vitro biological properties, HA compacts with grain size between 168 nm and 1.16 microm were assessed for in vitro bone cell-material interactions with human osteoblast cell line. Vinculin protein expression for cell attachment and bone cell proliferation using MTT assay showed that surfaces with finer grains provided better bone cell-material interactions than coarse-grained samples. Our results indicate simultaneous improvements in mechanical and biological properties in microwave sintered HA compacts with nanoscale grain size.
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