ArticlePsychology and aging2010
Loneliness predicts increased blood pressure: 5-year cross-lagged analyses in middle-aged and older adults.
Article in Psychology and aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04646642 (Psychological Health, Coping Strategies and Preferences of David Grant USAF Medical Center COVID-19 Deployers), which is not on this map. Cited by 247 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychological Health, Coping Strategies and Preferences of David Grant USAF Medical Center COVID-19 Deployers: A Critical Needs Assessment
Who cites it
247 citing papers in PubMed, 11 syntheses or guidelines pooled it, 729 citations in OpenAlex.
- A Systematic Review of Quantitative Studies of Depression and Loneliness in Black Women with Hypertension in the United States.Journal of racial and ethnic health disparities · 2026Pooled it
- Tackling social disconnection: an umbrella review of RCT-based interventions targeting social isolation and loneliness.BMC public health · 2024Pooled it
- Social Isolation, Loneliness, and Cardiovascular Mortality: The Role of Health Care System Interventions.Current cardiology reports · 2024Pooled it
- Associations between constructs related to social relationships and mental health conditions and symptoms: an umbrella review.BMC psychiatry · 2023Pooled it
- The impact of loneliness and social isolation on health state utility values: a systematic literature review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Pooled it
- The Effectiveness of Technology-Based Interventions for Reducing Loneliness in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in psychology · 2021Pooled it
- Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework.Journal of the Royal Society of Medicine · 2020Pooled it
- The Stability and Change of Loneliness Across the Life Span: A Meta-Analysis of Longitudinal Studies.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2020Pooled it
- Associations between loneliness and perceived social support and outcomes of mental health problems: a systematic review.BMC psychiatry · 2018Pooled it
- Pooled it
- Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies.Heart (British Cardiac Society) · 2016Pooled it
- Outcomes of Interventions for Reducing Loneliness in Elderly Patients in the Cardiac Intensive Care Unit: A Randomized Controlled Trial.Gerontology · 2025Trial
- A Pilot Randomized Trial of Engage Psychotherapy to Increase Social Connection and Reduce Suicide Risk in Later Life.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Trial
- Trial
- The relationship between frailty status and psychosocial indices in older Korean adults.GeroScience · 2026Article
- Observational
- Age-Moderated Associations Between Social Support and Loneliness in Latino Adults with Cardiovascular Disease.Hispanic health care international : the official journal of the National Association of Hispanic Nurses · 2026Article
- Blood pressure variability and frailty: mechanisms, evidence, and clinical implications.International urology and nephrology · 2026Review
- Loneliness Biases Social Engagement Decisions: Evidence From Value-Based Choice Models.Annals of the New York Academy of Sciences · 2026Article
187 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Loneliness is a prevalent social problem with serious physiological and health implications. However, much of the research to date is based on cross-sectional data, including our own earlier finding that loneliness was associated with elevated blood pressure (Hawkley, Masi, Berry & Cacioppo, 2006). In this study, we tested the hypothesis that the effect of loneliness accumulates to produce greater increases in systolic blood pressure (SBP) over a 4-year period than are observed in less lonely individuals. A population-based sample of 229 50- to 68-year-old White, Black, and Hispanic men and women in the Chicago Health, Aging, and Social Relations Study was tested annually for each of 5 consecutive years. Cross-lagged panel analyses revealed that loneliness at study onset predicted increases in SBP 2, 3, and 4 years later (B = 0.152, SE = 0.091, p < .05, one-tailed). These increases were cumulative such that higher initial levels of loneliness were associated with greater increases in SBP over a 4-year period. The effect of loneliness on SBP was independent of age, gender, race or ethnicity, cardiovascular risk factors, medications, health conditions, and the effects of depressive symptoms, social support, perceived stress, and hostility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.