Evidence map›Paper›PMID 20230064›Full record

ArticleAnalytical chemistry2010

Comparative glycomics using a tetraplex stable-isotope coded tag.

Michael J Bowman, Joseph Zaia

Abstract read
In one paragraph

Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 64 citations in OpenAlex.

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  15. Review
  16. Quantitative glycomics strategies.Molecular & cellular proteomics : MCP · 2013
    Review
  17. Article
  18. Review
  19. Structural glycomic analyses at high sensitivity: a decade of progress.Annual review of analytical chemistry (Palo Alto, Calif.) · 2013
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael J BowmanBoston University School of Medicine, Department of Biochemistry, Center for Biomedical Mass Spectrometry, Boston, Massachusetts 02118, USA.
Joseph Zaia
Boston University · US

Funding

XI INTERNATIONAL SYMPOSIUM ON AMYLOIDOSISP41RR010888 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 1996 to 2011
$18.6M
Post-biosynthetic Remodeling of Heparan SulfateR01HL098950 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2010 to 2013
$1.6M
Glycosaminoglycan-Protein BindingR01HL074197 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2003 to 2006
$1.3M
NCRR NIH HHS P41 RR010888NCRR NIH HHS P41RR10888NHLBI NIH HHS R01 HL074197NHLBI NIH HHS R01 HL098950NHLBI NIH HHS R01HL74197
6 · The paper itself

Abstract

This study illustrates the utility of tetraplex stable isotope coded tags in mass spectrometric glycomics using three carbohydrate classes. The teteraplex tags allow for the direct comparison of glycan compositions within four samples using capillary scale hydrophilic interaction chromatography with online mass spectrometry. In addition, the ability to discern glycan structural isomers is shown based on the tandem mass spectra of each composition using nanospray ionization. Results are shown for chondroitin sulfate proteoglycans, low molecular weight heparins, full length heparins, and N-glycans from alpha-1-acid glycoproteins from four mammalian species. The data demonstrate the value of the tetraplex stable isotope tagging approach for producing high-quality glycomics compositional profiling and fine structural analysis.

Indexed as

Chondroitin SulfatesGlycomicsGlycoproteinsHeparinHumansIsotope LabelingPolysaccharidesProteoglycansTandem Mass SpectrometryChondroitin SulfatesGlycoproteinsHeparinPolysaccharidesProteoglycans

Identifiers

PMID20230064
PMCPMC2854645
OpenAlexW2012652312

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.